DNA Origami and G-Quadruplex Hybrid Complexes Induce Size Control of Single-Walled Carbon Nanotubes via Biological Activation
DNA Origami and G-Quadruplex Hybrid Complexes Induce Size Control of Single-Walled Carbon Nanotubes via Biological Activation
复制标题
DOI：
10.1021/acsnano.8b02720
复制
发表时间：
2018-08-01
期刊：
影响因子：
17.1
通讯作者：
Belcher, Angela M.
中科院分区：
文献类型：
--
作者：
Atsumi, Hiroshi;Belcher, Angela M.
DNA自组装使纳米结构的可编程制造成为可能，这些纳米结构与纳米材料的结合提供了多种应用。在这里，我们开发了一种切割预定长度的单壁碳纳米管（SWNTs）的方法，使用DNA折纸和g -四重杂化复合物。该方法基于DNA的特点：(1)用DNA包裹单壁碳纳米管，提高单壁碳纳米管在水中的分散性；(2)利用g -四重体DNA将血红蛋白限制在单壁碳纳米管附近，增强血红蛋白对过氧化氢的生物活性；(3)形成DNA折纸平台，以允许g -四联体的精确放置，从而实现尺寸控制。DNA的这些集成特性允许暂时有效地将单壁碳纳米管切割成所需的长度，从而扩大了单壁碳纳米管在纳米电子学、纳米医学、纳米材料和量子物理学以及基础研究领域的应用。
DNA self-assembly has enabled the programmable fabrication of nanoarchitectures, and these nano-architectures combined with nanomaterials have provided several applications. Here, we develop an approach for cutting single-walled carbon nanotubes (SWNTs) of predetermined lengths, using DNA origami and G-quadruplex hybrid complexes. This approach is based on features of DNA: (1) wrapping SWNTs with DNA to improve the dispersibility of SWNTs in water; (2) using G-quadruplex DNA to confine hemin in close proximity to SWNTs and enhance the biological activation of hydrogen peroxide by hemin; and (3) forming DNA origami platforms to allow for the precise placement of G-quadruplexes, enabling size control. These integrated features of DNA allow for temporally efficient cutting of SWNTs into desired lengths, thus expanding the availability of SWNTs for applications in the fields of nanoelectronics, nanomedicine, nanomaterials, and quantum physics, as well as in fundamental studies.