Divergent Synthesis of Hydro-γ-Carbolines and Multisubstituted Indoles through Grob Fragmentation/Mannich Cyclization
Divergent Synthesis of Hydro-γ-Carbolines and Multisubstituted Indoles through Grob Fragmentation/Mannich Cyclization
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DOI：
10.1002/asia.201600980
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发表时间：
2016-10-01
影响因子：
4.1
通讯作者：
Zu, Liansuo
中科院分区：
文献类型：
--
作者：
Jiang, Long;Yu, Yuanyuan;Zu, Liansuo
报道了一种独特的氢化-伽马-卡宾和多取代吲哚的发散合成策略。立体化学结果和对照实验表明，这些反应可能是通过Grob裂解/Mannich环化进行的，而不是协同氮杂-片呐醇重排进行的。
A distinct strategy for the divergent synthesis of hydro-gamma-carbolines and multisubstituted indoles is reported. The stereochemical outcomes and a control experiment indicate that the reactions likely proceed through Grob fragmentation/Mannich cyclization rather than a concerted aza-pinacol rearrangement.