OBSERVATIONS ON THE DEVELOPMENT OF RESISTANCE TO VIVAX MALARIA
OBSERVATIONS ON THE DEVELOPMENT OF RESISTANCE TO VIVAX MALARIA
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DOI：
10.1016/0035-9203(48)90020-0
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发表时间：
1948-01-01
影响因子：
2.2
通讯作者：
BLACKBURN, CRB
中科院分区：
文献类型：
--
作者：
BLACKBURN, CRB
所提供的病例史似乎表明可以对间日疟产生耐受性和免疫力。这些反应是对滋养体的反应，而不是对间日疟原虫的红细胞外形式的反应。对间日疟原虫的耐受性不具有菌株特异性，但免疫力绝对如此。具有完全耐受性和免疫力的受试者，除了外周血中有少量滋养体外，不仅不会表现出疾病的临床症状，而且暴露于各种身体困难也不会诱发这种症状的出现。外周血中不存在配子母细胞，因此蚊子不会被此类免疫个体的血液感染。
Case histories are presented which seem to indicate that both tolerance and immunity can be developed for vivax malaria. Such reactions are in response to the trophozoite rather than to exo-erythro-cytic forms of Plasmodium vivax. Tolerance for P. vivax is not strain-specific, but immunity is definitely so. Subjects with complete tolerance and solid immunity not only show no clinical symptoms of the disease beyond a few trophozoites in the peripheral blood, but exposure to all types of physical hardships could not induce such symptoms to develop. Game-tocytes are not present in peripheral blood and mosquitoes could not be infected by the blood of such immune individuals.