Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks.

Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks.
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DOI:
10.3389/fcvm.2018.00113
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发表时间:
2018
影响因子:
3.6
通讯作者:
Koenen RR
Koenen RR
中科院分区:
医学3区
文献类型:
--
作者:
Dickhout A;Koenen RR

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细胞外小泡(EV)的领域正在迅速扩大,心血管疾病也是如此。EV除了在细胞间的交流中具有令人兴奋的作用外,还有可能成为优秀的生物标志物,因为它们的计数、含量和来源可能提供关于心血管疾病病理生理学的有用信息。各种研究已经表明EV计数和内容与心血管疾病的关系。然而,电动汽车的研究因几个因素而变得复杂,最明显的是电动汽车的小尺寸。本文就EV相关方法及其作为生物标志物应用的优缺点作一综述。
The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovascular diseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovascular disorders. Various studies have already indicated associations of EV counts and content with cardiovascular diseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.
跨不同流式细胞仪平台的微粒枚举的标准化:多中心协作研讨会的结果。
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