Further intracellular proteins and signaling pathways regulated by angiotensin-(1–7) in human endothelial cells

Further intracellular proteins and signaling pathways regulated by angiotensin-(1–7) in human endothelial cells
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人内皮细胞中血管紧张素-(1â7) 调节的其他细胞内蛋白和信号通路

DOI:
10.1016/j.dib.2016.12.004
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发表时间:
2017
期刊:
影响因子:
1.2
通讯作者:
Walther T
Walther T
中科院分区:
--
文献类型:
--
作者:
Meinert C;Kohse F;Boehme I;Gembardt F;Tetzner A;Wieland T;Greenberg B;Walther T

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2016年,Meinert等人(doi:10.1016/j.jprot.2015.09.020)发表了在人脐静脉内皮细胞(HUVEC)中由七肽血管紧张素(Ang)-(1-7)调节的蛋白质阵列中的前25种蛋白质以及不同时间点的前10种细胞内信号级联。这篇支持性数据文章显示了在1 h、3 h、6 h和9 h时间点,Ang-(1-7)在人内皮细胞中刺激的其他蛋白质和途径。用Ang-(1-7)刺激HUVECs,通过抗体微阵列鉴定其调控蛋白。使用生物信息学软件IPA将调节蛋白与代谢途径关联。
In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1–7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1–7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1–7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.
DOI: 10.1016/j.jprot.2015.09.020
发表时间: 2016-01-01
影响因子: 3.3
作者:
Meinert C;Gembardt F;Böhme I;Tetzner A;Wieland T;Greenberg B;Walther T
通讯作者: Walther T
G-蛋白â偶联受体 MrgD 是血管紧张素-(1â7) 的受体,涉及腺苷酸环化酶、cAMP 和磷酸激酶 A
DOI: 10.1161/hypertensionaha.116.07572
发表时间: 2016
期刊: Hypertension
影响因子: 8.3
作者:
Tetzner;Gebolys K;Meinert C;Klein S;Uhlich A;Trebicka J;Villacañas Pérez O;Walther T
通讯作者: Walther T