Sleep enhances serum interleukin-7 concentrations in humans
Sleep enhances serum interleukin-7 concentrations in humans
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DOI：
10.1016/j.bbi.2007.04.004
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发表时间：
2007-11-01
影响因子：
15.1
通讯作者：
Born, Jan
中科院分区：
文献类型：
--
作者：
Benedict, Christian;Dimitrov, Stoyan;Born, Jan
越来越多的证据表明睡眠对免疫功能有有益影响。人类研究表明，睡眠促进 T 细胞介导的适应性免疫功能，包括抗原特异性抗体的形成。沿着这个思路，我们的目的是分离睡眠和昼夜节律对循环白细胞介素 7 (IL-7) 和白细胞介素 15 (IL-15) 的影响。这些细胞因子在初始 T 细胞和记忆 T 细胞数量的稳态调节中发挥着关键作用，并且对于记忆 T 细胞的分化至关重要。对 18 名男性的血清 IL-7 浓度和 CD14+ 单核细胞上膜结合 IL-15 (mIL-15) 的表达进行了两次测量：一次是在定期的 24 小时睡眠觉醒周期中，另一次是在 24 小时的连续觉醒周期中。睡眠期间，尤其是晚睡期间，血清 IL-7 浓度与清醒时相比明显增加（P < 0.05）。单核细胞上的 mIL-15 密度因睡眠而保持不变。 IL-7 浓度的睡眠依赖性增加与快速眼动睡眠的增加有关，但与睡眠期间 GH、皮质醇或去甲肾上腺素的浓度无关。这些发现与睡眠对与 T 细胞记忆形成相关的 T 细胞功能产生支持性影响的观点一致。 (C) 2007 Elsevier Inc. 保留所有权利。
Growing evidence points towards a beneficial effect of sleep on immune function. Human studies indicate that the T cell mediated adaptive immune function including formation of antigen specific antibodies is facilitated by sleep. Along this line, here we aimed to dissociate the effect of sleep and circadian rhythm on circulating interleukin-7 (IL-7) and interleukin-15 (IL-15). These cytokines play a key role in the homeostatic regulation of naive and memory T cell numbers and are critical for the differentiation of memory T cells. Serum IL-7 concentration and expression of membrane-bound IL-15 (mIL-15) on CD14(+) monocytes were measured in 18 men on two occasions: once during a regular 24-h sleep wake cycle and another time during a 24-h period of continuous wakefulness. During sleep and especially during late sleep serum IL-7 concentrations were distinctly increased as compared to wakefulness (P < 0.05). mIL-15 density on monocytes remained unchanged by sleep. The sleep-dependent increase in IL-7 concentration was associated with increased REM sleep.. but did not correlate with concentrations of GH, cortisol or norepinephrine during sleep. The findings concur with the notion of a supportive influence of sleep on T cell function related to formation of T cell memory. (C) 2007 Elsevier Inc. All rights reserved.