Maturational changes in peripheral lymphocyte subsets pertinent to monitoring human immunodeficiency virus-infected Chinese pediatric patients
Maturational changes in peripheral lymphocyte subsets pertinent to monitoring human immunodeficiency virus-infected Chinese pediatric patients
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DOI：
10.1128/cdli.8.5.926-931.2001
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发表时间：
2001-09-01
期刊：
影响因子：
--
通讯作者：
Kwok, MY
中科院分区：
文献类型：
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作者：
Kam, KM;Leung, WL;Kwok, MY
基于采用标准化流式细胞术技术对从出生到成年的五个年龄组的 212 份华裔个体的外周血样本进行检测的结果，我们研究了与监测人类免疫缺陷病毒 (HIV) 感染的中国儿童群体相关的成熟过程。虽然外周血总白细胞数量和淋巴细胞百分比从出生到成年有所下降，但在所有研究年龄组中，CD3(+) T 淋巴细胞百分比保持稳定。 CD3(+) CD4(+) (T辅助细胞) 细胞的数量在出生后第一年显着下降，随后下降速度较慢，成年前略有增加。然而，CD3(+) CD8(+)（T 抑制）细胞的趋势在所有年龄段的个体中都有增加。 CD19(+) CD3(-)（B 细胞）的数量仅在生命的第一年增加，然后稳步下降，而自然杀伤（NK）细胞则表现出相反的模式。与白人人群研究结果的比较表明，与白人儿童相比，中国儿童一岁后外周辅助性 T 细胞和抑制性 T 细胞数量均较低。与白人相比，中国人一岁后 B 细胞计数较低，NK 细胞计数较高。重要的是，为每个 HIV 感染人群建立淋巴细胞亚群的正常范围，以监测 HIV 感染的儿科患者。
On the basis of results of testing of 212 peripheral blood samples from ethnic Chinese individuals in five age groups, ranging from birth to adulthood, by standardized flow cytometry techniques, we studied the maturational processes that are pertinent to monitoring the human immunodeficiency virus (HIV)-infected Chinese pediatric population. While the numbers of peripheral total white cells and percent lymphocytes declined from birth to adulthood, the percent CD3(+) T lymphocytes was steady among all age groups studied. The numbers of CD3(+) CD4(+) (T-helper) cells decreased markedly after the first year of life, followed by a slower decline afterward and then a slight increase before adulthood. The trend for CD3(+) CD8(+) (T-suppressor) cells, however, was an increase among individuals of all age ranges. The numbers of CD19(+) CD3(-) (B cells) increased only during the first year of life and then declined steadily, while natural killer (NK) cells showed the opposite pattern. Comparison of the results with those of studies done with a Caucasian population showed that both peripheral T-helper and T-suppressor cell numbers were low after the first year of life in the Chinese pediatric population in comparison with those in a Caucasian pediatric population. Lower B-cell counts and higher NK-cell counts were seen after the first year of life in the Chinese population than in the Caucasian population. It is important that for each HIV-infected population normative ranges of the lymphocyte subset be established to monitor HIV-infected pediatric patients.