Lipid trafficking at endoplasmic reticulum-chloroplast membrane contact sites
Lipid trafficking at endoplasmic reticulum-chloroplast membrane contact sites
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DOI：
10.1016/j.ceb.2015.03.004
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发表时间：
2015-08-01
影响因子：
7.5
通讯作者：
Jouhet, Juliette
中科院分区：
文献类型：
--
作者：
Block, Maryse A.;Jouhet, Juliette
植物细胞中甘油脂合成的特点是脂质在内质网 (ER) 和叶绿体之间的强烈运输。最初，脂肪酸在叶绿体内合成，并被输出到内质网，在那里它们被用来构建磷脂和三酰甘油。最终，这些磷脂的衍生物返回叶绿体，形成半乳糖脂、单半乳糖二酰甘油和二半乳糖二酰甘油，它们是光合膜的主要和必需的脂质。脂质运输被认为是通过连接两个细胞器的膜接触位点（MCS）转运的。在这里，我们回顾了最近对 ER-叶绿体 MCS 和叶绿体与 ER 之间的脂质运输的见解。
Glycerolipid synthesis in plant cells is characterized by an intense trafficking of lipids between the endoplasmic reticulum (ER) and chloroplasts. Initially, fatty acids are synthesized within chloroplasts and are exported to the ER where they are used to build up phospholipids and triacylglycerol. Ultimately, derivatives of these phospholipids return to chloroplasts to form galactolipids, monogalactosyldiacylglycerol and digalactosyldiacylglycerol, the main and essential lipids of photosynthetic membranes. Lipid trafficking was proposed to transit through membrane contact sites (MCSs) connecting both organelles. Here, we review recent insights into ER-chloroplast MCSs and lipid trafficking between chloroplasts and the ER.