MITOCHONDRIAL MATURATION DURING NEURONAL DIFFERENTIATION INVIVO AND INVITRO
MITOCHONDRIAL MATURATION DURING NEURONAL DIFFERENTIATION INVIVO AND INVITRO
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DOI：
10.1016/0248-4900(91)90051-n
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发表时间：
1991-01-01
影响因子：
2.7
通讯作者：
CROIZAT, B
中科院分区：
文献类型：
--
作者：
CORDEAULOSSOUARN, L;VAYSSIERE, JL;CROIZAT, B
在分化的神经元细胞中，无论是在胎鼠皮层神经元的原代培养物中，还是在大鼠大脑皮层成熟过程中，都遵循了Ekadon的进化。 总线粒体蛋白（mt-蛋白）的变化进行了评价，并在mt-蛋白质模式的定性变化进行了分析，使用蛋白质印迹技术。 在培养的神经元中mt蛋白含量的演变类似于在大鼠脑成熟过程中观察到的。 线粒体在神经发生过程中表现出明显的变化，特别是观察到伴随着神经发生的连续步骤的线粒体质量的爆发。 有迹象表明，在神经元发育过程中，线粒体的蛋白质装备经历了变化。 虽然需要更多的工作来建立这些相关性的意义，目前的数据可能表明，在神经发生中的重要作用的cervion。
The evolution of the mitochondrion has been followed within differentiating neuronal cells, both in primary cultures of neurons from fetal rat cortex and during rat brain cortex maturation. Changes in total mitochondrial proteins (mt-proteins) were evaluated, and qualitative changes in the mt-proteins pattern were analyzed using the Western blot technique. The evolution of mt-protein contents in cultured neurons resembles what is observed during rat brain maturation. The mitochondrion exhibits pronounced changes in the course of neurogenesis, in particular, bursts of mitochondrial masses accompanying the successive steps of neurogenesis are observed. There are indications that protein equipment of mitochondria during neuronal development undergoes variations. Although more work is required to establish the significance of these correlations, the present data might suggest an important role of the mitochondrion in neurogenesis.