Cochlear spiral ganglion cell degeneration in wild-caught mice as a function of age
Cochlear spiral ganglion cell degeneration in wild-caught mice as a function of age
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DOI：
10.1016/0378-5955(96)00100-1
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发表时间：
1996-10-01
期刊：
影响因子：
2.8
通讯作者：
Keithley, EM
中科院分区：
文献类型：
--
作者：
Dazert, S;Feldman, ML;Keithley, EM
人类老年性耳聋是一种与年龄相关的双侧感音神经性听力障碍，通常与耳蜗毛细胞和螺旋神经节细胞（SGC）变性有关，主要发生在耳蜗基底转，但也存在于耳蜗根尖转。对老年大鼠和沙鼠耳蜗的研究发现，在耳蜗的顶端和基部有大量的SGCs丢失。另一方面，基因上近亲繁殖的老年小鼠，似乎有不同数量的SGC损失，在一些品系的动物生命周期的早期就开始了，在基础阶段最大。研究了三个年龄组的野生捕获小鼠和实验室饲养小鼠，以确定SGC变性的模式。在18-19个月大的动物中，主要的SGCs丢失发生在基底转向（与2-3个月相比丢失49%），其次是根尖转向（31%）。28-31月龄动物最大的SGC损失发生在根尖（76%）和基部（74%）。因此，该品系小鼠与其他啮齿动物相似，神经节的两端都受到与衰老相关的SGC变性的影响。
Presbyacusis in humans is an age-related bilateral sensorineural hearing impairment generally associated with degeneration of cochlear hair cells and spiral ganglion cells (SGC) predominantly in the basal turn but present in the apical turn. Investigations of cochleas of aged rats and gerbils reveal a large loss of SGCs in the apical as well as the basal turns. Genetically inbred aged mice, on the other hand, seem to have variable amounts of SGC loss beginning in some strains very early in the life span of the animals and greatest in the basal turn.Three age groups of wild-caught, then laboratory-bred, mice were investigated to determine the pattern of SGC degeneration. In 18-19-month-old animals the main loss of SGCs occurred in the basal turn (49% loss compared to 2-3 months) followed by the apical turn (31%). The greatest SGC losses in the 28-31-month-old animals were in both the apical (76%) and basal turns (74%). Thus, this strain of mice is similar to other rodents in that both ends of the ganglion are affected by SGC degeneration associated with aging.