A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres
A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres
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DOI：
10.1088/1361-6439/ac0515
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发表时间：
2021-07-01
影响因子：
2.3
通讯作者：
Yang, Xin
中科院分区：
文献类型：
--
作者：
Mikhaylov, Roman;Martin, Mercedes Stringer;Yang, Xin
基于表面声波（saw）的声流体装置在生物医学研究中被广泛应用于细胞的操作和分离。在这项工作中，我们开发了一种易于使用的制造工艺来制造由SAW数字间换能器（IDT）和聚二甲基硅氧烷微通道组成的声流装置。IDT是使用柔性印刷电路板制造的，该电路板带有数字间电极，与压电基板机械耦合。通过在玻片上3D打印实现了一种新的微通道成型技术，并通过构建声流控器件的微通道进行了演示。用于构造器件的灵活夹紧机构允许在IDT和微通道之间进行可重构绑定。这种独特的结构使得声流装置能够通过旋转IDT或微通道来调整微通道和SAW传播之间的角度，而无需重新制造。通过将聚苯乙烯微球聚集角设置为-5度，0度，6度和15度来证明角度的调节。声能密度测量表明，微球在器件内的聚集速度可以通过输入功率精确控制。该制造工艺具有可重构性和快速成型的优点，有利于制备更广泛应用的声流体器件。
Acoustofluidic devices based on surface acoustic waves (SAWs) have been widely applied in biomedical research for the manipulation and separation of cells. In this work, we develop an accessible manufacturing process to fabricate an acoustofluidic device consisting of a SAW interdigital transducer (IDT) and a polydimethylsiloxane microchannel. The IDT is manufactured using a flexible printed circuit board pre-patterned with interdigital electrodes that is mechanically coupled with a piezoelectric substrate. A new microchannel moulding technique is realised by 3D printing on glass slides and is demonstrated by constructing the microchannel for the acoustofluidic device. The flexible clamping mechanism, used to construct the device, allows the reconfigurable binding between the IDT and the microchannel. This unique construction makes the acoustofluidic device capable of adjusting the angle between the microchannel and the SAW propagation, without refabrication, via either rotating the IDT or the microchannel. The angle adjustment is demonstrated by setting the polystyrene microsphere aggregation angle to -5 degrees, 0 degrees, 6 degrees, and 15 degrees. Acoustic energy density measurements demonstrate the velocity of microsphere aggregation in the device can be accurately controlled by the input power. The manufacturing process has the advantages of reconfigurability and rapid-prototyping to facilitate preparing acoustofluidic devices for wider applications.