QUANTITATION OF HUMAN SYNOVIAL MAST-CELLS IN RHEUMATOID-ARTHRITIS AND OTHER RHEUMATIC DISEASES
QUANTITATION OF HUMAN SYNOVIAL MAST-CELLS IN RHEUMATOID-ARTHRITIS AND OTHER RHEUMATIC DISEASES
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DOI：
10.1002/art.1780270803
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发表时间：
1984-01-01
影响因子：
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通讯作者：
GRAZIANO, FM
中科院分区：
文献类型：
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作者：
GODFREY, HP;ILARDI, C;GRAZIANO, FM
检查了14名类风湿性关节炎（RA）患者、7名其他风湿性疾病患者和10名无明显关节疾病患者的滑膜切片。RA和其他风湿性疾病患者的滑膜肥大细胞/血管显著多于无关节疾病的患者（分别为0.49和0.20 vs. 0.03）。与无关节疾病的患者相比，他们的肥大细胞总数/10个视野也显著更多（分别为9.9和5.0 vs. 0.4）。在类风湿组中，活动期患者的肥大细胞总数/10个视野比临床认为的终末期患者多（P < 0.05）。在任何患者中均未发现滑膜嗜碱性粒细胞。所有组的滑膜血管分布相似（2.3支血管/视野）。滑膜肥大细胞在类风湿关节炎和其他风湿性疾病中的作用仍有待确定。
Sections of synovial membranes were examined from 14 patients with rheumatoid arthritis (RA), 7 with other rheumatic diseases and 10 with no apparent joint disease. Patients with RA and other rheumatic diseases had significantly more synovial mast cells/vessel than patients with no joint disease (0.49 and 0.20, respectively, vs. 0.03). They also had significantly more total mast cells/10 fields than patients with no joint disease (9.9 and 5.0, respectively, vs. 0.4). Within the rheumatoid group, patients with active disease had more total mast cells/10 fields than patients clinically considered to have end-stage disease (P < 0.05). Synovial basophils were not identified in any patient. Synovial vascularity was similar for all groups (2.3 vessels/field). The role of the synovial mast cell in RA and other rheumatid diseases remains to be determined.