The incidence of fracture among patients with inflammatory dowel disease - A population-based cohort study
The incidence of fracture among patients with inflammatory dowel disease - A population-based cohort study
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DOI：
10.7326/0003-4819-133-10-200011210-00012
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发表时间：
2000-11-21
影响因子：
39.2
通讯作者：
Yu, BN
中科院分区：
文献类型：
--
作者：
Bernstein, CN;Blanchard, JF;Yu, BN
背景资料：炎症性肠道疾病中骨质减少高患病率的临床意义尚不清楚。目的：确定炎症性肠道疾病患者的骨折发生率是否增加。设计：基于人群的匹配队列研究。地点：加拿大马尼托巴。患者：马尼托巴大学IBD数据库中的炎性鲍尔病患者（n = 6027）与10名随机选择的无炎症性肠病的普通人群相匹配（n = 60 270）按年龄、性别和居住地划分。髋部骨折住院的发生率是根据出院摘要确定的。门诊医疗账单记录和出院摘要被用来计算脊柱、肋骨和前臂骨折的发生率。根据1984年至1997年随访的人-年计算发生率。结果：患有炎性bower病的人脊柱骨折的发生率显著增加（发病率比[IRR]，1.74 [95% CI，1.34 - 2.24]; P < 0.001），髋关节（IRR，1.59 [CI，1.27 - 2.00]; P < 0.001），腕/前臂（IRR，1.33 [CI，1.11 - 1.58]; P = 0.001），肋骨（IRR，1.25 [CI，1.02 - 1.52]; P = 0.03），任何这些骨折（IRR，1.41 [Cl，1.27至1.56]; P < 0.001）。炎症性肠病患者的骨折发生率比普通人群高40%。
Background: The clinical significance of the high prevalence of osteopenia in inflammatory bowel disease is unclear.Objective: To determine whether persons with inflammatory bowel disease have increased incidence of fracture.Design: Population-based matched cohort study.Setting: Manitoba, Canada.Patients: Patients with inflammatory bower disease in the University of Manitoba IBD Database (n = 6027) were matched to 10 randomly selected persons in the general population without inflammatory bowel disease (n = 60 270) by year, age, sex, and postal area of residence.Measurements: The incidence of hospitalization for hip fracture was determined on the basis of hospital discharge abstracts. Outpatient medical billing records and hospital discharge abstracts were used to calculate the incidence of spine, rib, and forearm fractures. Rates were calculated on the basis of person-years of follow-up for 1984 to 1997.Results: Persons with inflammatory bower disease had significantly increased incidence of fractures at the spine (incidence rate ratio [IRR], 1.74 [95% Cl, 1.34 to 2.24]; P < 0.001), hip (IRR, 1.59 [Cl, 1.27 to 2.00]; P < 0.001), wrist/forearm (IRR, 1.33 [Cl, 1.11 to 1.58]; P = 0.001), and rib (IRR, 1.25 [Cl, 1.02 to 1.52]; P = 0.03) and of any of these fractures (IRR, 1.41 [Cl, 1.27 to 1.56]; P < 0.001).Conclusion: The incidence of fracture among persons with inflammatory bowel disease is 40% greater than that in the general population.