Potassium base-catalyzed redox isomerization of propargylic alcohols to chalcones
Potassium base-catalyzed redox isomerization of propargylic alcohols to chalcones
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DOI：
10.1080/00397911.2022.2152695
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发表时间：
2023-01
影响因子：
2.1
通讯作者：
M. Sai;Takatoki Mizuno
中科院分区：
文献类型：
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作者：
M. Sai;Takatoki Mizuno
查尔酮衍生物广泛存在于生物活性物质、天然产物和药物中。在这项研究中，我们开发了一种KO t Bu/DMF催化体系，通过异构化1-和3-位带有芳基取代基的炔丙醇来高效合成查耳酮衍生物。机理研究证实，1，3-氢化物移位是反应成功的关键过程。该方法不涉及过渡金属的使用，具有经济和环境效益。图形摘要
Abstract Chalcone derivatives are frequently found in bioactive compounds, natural products, and pharmaceuticals. In this study, we developed a KO t Bu/DMF catalytic system to efficiently synthesize chalcone derivatives by isomerizing propargylic alcohols bearing aryl substituents at the 1- and 3-positions. Mechanistic investigations confirmed that a 1,3-hydride shift was the key process for the successful reaction. Our method does not involve the use of transition metals and possesses economic and environmental benefits. Graphical Abstract