Correlation of quality of life with clinical symptoms and signs at the time of glaucoma diagnosis.
Correlation of quality of life with clinical symptoms and signs at the time of glaucoma diagnosis.
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发表时间：
1998
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通讯作者：
Mills Rp
中科院分区：
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作者：
Mills Rp
目的：在一个大的青光眼患者队列中，研究诊断时视功能的临床指标与患者报告的症状和健康状况指标之间的关系。受试者和方法607例青光眼初始治疗合作研究（CIGTS）患者在入组时接受了标准化的视力和视野检查。此外，他们还完成了一个与健康相关的生活质量工具，其中包括视觉活动问卷（VAQ），疾病影响概况（SIP），症状和合并症图表，关于他们对失明的担忧程度的问题，以及许多其他项目。结果：SIP总分和维度得分与视力和视野测量值仅弱相关，且不显著。VAQ总分和子量表评分，特别是周边视觉子量表，与视力和视野评分，特别是较好眼的视力和视野评分相关性较弱且显著。对失明的担忧和青光眼引起的症状与视力差的眼睛的视野评分相关性很弱，但很显著。试图通过不同的视野评分来改善相关性，包括分数中仅包括旁中央和中央周围的测试位置，以及模拟双眼视野分数，在很大程度上是不成功的。结论：在诊断时，大多数患者相对没有脑胶质瘤引起的损害，因此临床措施是患者对健康相关生活质量感知的不良预测因素。视觉特异性VAQ和青光眼相关症状评分在CIGTS入组时与临床指标的相关性优于通用SIP。
PURPOSE To examine the relationship between clinical measures of visual function and patient-reported measures of symptoms and health status in a large cohort of glaucoma patients at the time of diagnosis. SUBJECTS AND METHODS The 607 patients in the Collaborative Initial Glaucoma Treatment Study (CIGTS) received standardized examinations of visual acuity and visual field at enrollment. In addition, they completed a health-related quality-of-life instrument, which included the Visual Activities Questionnaire (VAQ), Sickness Impact Profile (SIP), a symptom and a comorbidity chart, a question about their degree of worry about becoming blind, and many other items. RESULTS The SIP total and dimension scores correlated only weakly, and not significantly, with visual acuity and visual field measures. The VAQ total and subscale scores, particularly the peripheral vision subscale, correlated weakly and significantly with visual acuity and visual field scores, especially those from the better eye. Worry about blindness and symptoms attributed to glaucoma correlated weakly but significantly to visual field scores from the worse eye. Attempts to improve correlations by scoring the visual fields differently, including only paracentral and pericentral test locations in the scores, and simulating binocular visual field scores were largely unsuccessful. CONCLUSIONS At diagnosis, most patients were relatively free of glaucoma-induced impairments, so clinical measures were poor predictors of a patient's perception of health-related quality of life. The vision-specific VAQ and glaucoma-related symptom score correlated better than the generic SIP with clinical measures at the time of enrollment into CIGTS.