[A case of Legionnaires' disease due to aspiration of hot spring water and isolation of Legionella pneumophila from hot spring water].
[A case of Legionnaires' disease due to aspiration of hot spring water and isolation of Legionella pneumophila from hot spring water].
复制标题
误吸温泉水并从温泉水中分离出嗜肺军团菌致军团病一例[J].
DOI：
10.11150/kansenshogakuzasshi1970.67.163
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
K. Torikai
中科院分区：
文献类型：
--
作者：
K. Mashiba;T. Hamamoto;K. Torikai
我们报告一例暴发性肺炎，是由于吸入污染的温泉水，并没有受到β-内酰胺类抗生素。我们怀疑患者患有军团病，并以红霉素治疗临床症状。军团菌不能从痰或肺活检材料中分离出来，但间接免疫荧光试验发现嗜肺军团菌血清组4的滴度升高。我们诊断该患者患有军团病，临床症状改善。此外，我们去了他参观的温泉，并试图分离军团菌。从浴室收集温泉水，从客房收集水、热水和淋浴水。在使用低pH方法后，将样品在BCYE α培养基上培养。用免疫兔血清凝集法分型。结果，我们成功地从浴池的温泉水（42摄氏度）中分离出嗜肺军团菌血清型4。其他样品均未分离出细菌。因此，我们相信这宗退伍军人病症是由吸入受污染的温泉水引致。军团病的感染途径尚不清楚。以前没有从日本温泉中分离出军团菌的报道。该病例将为研究日本军团病的感染途径提供重要信息。
We report a case of fulminant pneumonia that was due to aspiration of contaminated hot spring water and was not affected by beta-lactam antibiotics. We suspected that the patient had Legionnaires' disease and treated the clinical symptoms with erythromycin. Legionellaceae could not be isolated from sputum or lung biopsy material, but an elevated titer to Legionella pneumophila serogroup 4 was found by indirect immunofluorescence test. We diagnosed the patent as having Legionnaires' disease with improved clinical symptoms. Furthermore, we went to the hot spring that he visited and tried to isolate Legionellaceae. Hot spring water was collected from the bathroom and water, hot water, and shower water from the guest-room. After using a low-pH method, samples were cultured on BCYE alpha medium. Serogroups are classified by agglutination method with immune rabbit serum. As a result, we successfully isolated Legionella pneumophila serogroup 4 from hot spring water (42 degrees C) from the bath. No bacteria could be isolated from the other samples. Therefore, we believe that this case of Legionnaires' disease was caused by aspiration of contaminated hot spring water. The infection route of Legionnaires' disease is unclear. There are no previous reports of isolation of Legionellaceae from Japanese hot springs. This case would provide important information when considering the infection route of Legionnaires' disease in Japan.