Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone
Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone
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DOI：
10.1136/emj.2010.092288
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发表时间：
2011-04-01
影响因子：
3.1
通讯作者：
Dargan, P. I.
中科院分区：
文献类型：
--
作者：
Wood, D. M.;Greene, S. L.;Dargan, P. I.
背景 有证据表明，合成卡西酮甲氧麻黄酮（4-甲基甲卡西酮）的使用越来越多，尤其是在夜总会爱好者中。然而，只有两例甲氧麻黄酮中毒的病例报告。本研究的目的是报告使用甲氧麻黄酮所见的临床毒性模式。病例系列 我们描述了 15 名在自我报告甲氧麻黄酮使用后到急诊科就诊的患者。显着的临床特征包括 53.3% 的躁动、40% 的心动过速、20% 的收缩期高血压和 20% 的癫痫发作。百分之二十的人需要使用苯二氮卓类药物治疗，主要是为了控制躁动。所有患者均已出院，无后遗症。之前的用户报告表明，甲氧麻黄酮的使用与冷/蓝色周围环境有关；在我们的系列中的任何患者中都没有发现这种情况。 结论 在本系列中甲氧麻黄酮的毒性模式与 1-苄基哌嗪的毒性模式相似，1-苄基哌嗪最近被归入英国和欧盟滥用药物立法的范畴。在此基础上，再加上瑞典最近确认的甲氧麻黄酮相关死亡事件，我们认为应进行适当的评估，以确定甲氧麻黄酮的法律地位。
Background There is evidence of increasing use of the synthetic cathinone mephedrone (4-methylmethcathinone), particularly amongst clubbers. However, there have only two single case reports of mephedrone toxicity. The aim of this study is to report the pattern of clinical toxicity seen with mephedrone use.Case Series We describe 15 patients who presented to our Emergency Department following self-reported mephedrone use. Significant clinical features seen included agitation in 53.3%, tachycardia in 40%, systolic hypertension in 20% and seizures in 20%. Twenty per cent required treatment with benzodiazepines, predominantly for management of agitation. All patients were discharged with no sequelae. Previous user reports have suggested that mephedrone use is associated with cool/blue peripheries; this was not seen in any of the patients in our series.Conclusion The pattern of toxicity seen with mephedrone in this series is similar to that seen with 1-benzylpiperazine which has recently been classified under UK and EU misuse of drugs legislation. On the basis of this, together with a recent confirmed mephedrone related death in Sweden, we feel that appropriate assessments should be undertaken to determine the legal status of mephedrone.