The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.
The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.
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DOI：
10.1016/s0021-9258(18)34631-3
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发表时间：
1982-05
期刊：
影响因子：
--
通讯作者：
J. Massagué;M. Czech
中科院分区：
文献类型：
--
作者：
J. Massagué;M. Czech
从人和啮齿类动物组织中分离的Intaul细胞和膜已与人胰岛素样生长因子I（IGF-I）和胰岛素样生长因子I1（IGF-11）亲和交联。亲和标记材料的十二烷基硫酸盐-聚丙烯酰胺凝胶电泳分离出两种类型（I型和II型）的标记膜组分，其满足高亲和力生长因子受体的预期特性。I型受体由三种二硫键连接的形式（δ b = 350，000、320，000和290，000）组成，其结构类似于来自各种组织的膜制剂中的胰岛素受体形式（Massague，J.，Pilch，P. F.，捷克，M。P.（1980）hc. NutZ一张cd
Intaul cells and membranes isolated from several human and rodent tissues have been affinity-crosslinked tohuman ‘261-insulin-like growth factor I (IGF-I) and ‘261-insulin-like growth factor I1 (IGF-11). Dodecyl sulfate-polyacryalmide gel electrophoresis of the affinity-labeled material resolves two types (type I and type II) of labeled membrane components that fulfill the properties expected for high affinity growth factor receptors. Type I receptors consist of three disulfidelinked forms (&&= 350,000, 320,000 and 290,000) structurally similar to the insulin receptor forms in membrane preparations from various tissues (Massague, J., Pilch, P. F., and Czech, M. P.(1980) hc. NutZ. A cd