Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children
Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children
复制标题
DOI：
10.1016/j.numecd.2010.05.003
复制
发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Sartorio, A.
中科院分区：
文献类型：
--
作者：
Bedogni, G.;Gastaldelli, A.;Sartorio, A.
背景和目的：早发2型糖尿病（T2 DM）与肥胖、胰岛素抵抗和β细胞功能受损有关。非酒精性脂肪性肝病（NAFLD）可能是T2 DM的独立危险因素。我们调查了NAFLD和葡萄糖代谢之间的关系，在一个大样本的肥胖children.Methods和结果：共571肥胖儿童（57%男性和43%女性）年龄在8-18岁的连续研究在一个三级保健中心专门从事儿科肥胖。在排除B和C型肝炎和饮酒后，使用肝脏超声诊断NAFLD。进行口服葡萄糖耐量试验（OGTT）;使用胰岛素敏感性指数（ISI）评价胰岛素敏感性，使用胰岛素和葡萄糖的曲线下面积（AUC）增量比值（incAUCins/incAUCglu）评价β细胞功能。共有41%的肥胖儿童患有NAFLD。25%的NAFLD儿童存在糖耐量受损或T2 DM，而非NAFLD儿童为8%（p < 0.001）。与非NAFLD儿童相比，NAFLD儿童的体重指数（BMI）、空腹血糖、120分钟OGTT血糖、incAUCins/incAUCglu较高，ISI较低（p
Background and aims: Early onset type 2 diabetes mellitus (T2DM) is associated with obesity, insulin resistance and impaired beta-cell function. Non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for T2DM. We investigated the relationship between NAFLD and glucose metabolism in a large sample of obese children.Methods and Results: A total of 571 obese children (57% males and 43% females) aged 8-18 years were consecutively studied at a tertiary care centre specialised in paediatric obesity. Liver ultrasonography was used to diagnose NAFLD after exclusion of hepatitis B and C and alcohol consumption. Oral-glucose tolerance testing (OGTT) was performed; insulin sensitivity was evaluated by using the insulin sensitivity index (ISI) and beta-cell function by using the ratio between the incremental areas under the curve (AUC) of insulin and glucose (incAUCins/incAUCglu). A total of 41% of the obese children had NAFLD. Impaired glucose tolerance or T2DM was present in 25% of the children with NAFLD versus 8% of those without it (p < 0.001). Children with NAFLD had higher body mass index (BMI), fasting glucose, 120-min OGTT glucose, incAUCins/incAUCglu and lower ISI as compared with children without NAFLD (p