Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder.
Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder.
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DOI：
10.1017/s0033291712000840
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发表时间：
2013-01
影响因子：
6.9
通讯作者：
Blair, R. J. R.
中科院分区：
文献类型：
--
作者：
Blair, K. S.;Vythilingam, M.;Crowe, S. L.;McCaffrey, D. E.;Ng, P.;Wu, C. C.;Scaramozza, M.;Mondillo, K.;Pine, D. S.;Charney, D. S.;Blair, R. J. R.
本研究的目的是确定是否有创伤后应激障碍（PTSD）患者表现出招募的额叶和顶叶皮层的区域涉及自上而下的注意力控制在情绪干扰的存在和不存在的困难。未用药的PTSD患者（n=14），年龄，智商和性别匹配的个体暴露于创伤（n=15）和健康对照组（n=19）进行了测试的情感数Stroop任务。此外，通过功能性磁共振成像测量的血氧水平依赖性反应被记录。PTSD患者在负性干扰物存在下，表现出上级和低级额叶皮质以及顶叶皮质的侧部区域的募集中断。创伤比较个体表现出招募额顶叶区域的能力提高的迹象，这些区域涉及在分心条件下自上而下的注意力控制。这些结果是一致的建议，情绪反应可以干扰招聘涉及自上而下的注意力控制的区域，与PTSD患者的情绪反应的提高可能会导致这些地区的招聘的高度干扰。
This study aimed to determine whether patients with post-traumatic stress disorder (PTSD) show difficulty in recruitment of the regions of the frontal and parietal cortex implicated in top-down attentional control in the presence and absence of emotional distracters. Unmedicated individuals with PTSD (n=14), and age-, IQ- and gender-matched individuals exposed to trauma (n=15) and healthy controls (n=19) were tested on the affective number Stroop task. In addition, blood oxygen level-dependent responses, as measured via functional magnetic resonance imaging, were recorded. Patients with PTSD showed disrupted recruitment of lateral regions of the superior and inferior frontal cortex as well as the parietal cortex in the presence of negative distracters. Trauma-comparison individuals showed indications of a heightened ability to recruit fronto-parietal regions implicated in top-down attentional control across distracter conditions. These results are consistent with suggestions that emotional responsiveness can interfere with the recruitment of regions implicated in top-down attentional control ; the heightened emotional responding of patients with PTSD may lead to the heightened interference in the recruitment of these regions.