Response of Adolescents with Minimal Brain Dysfunction to Methylphenidate
Response of Adolescents with Minimal Brain Dysfunction to Methylphenidate
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轻度脑功能障碍青少年对哌醋甲酯的反应
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
M. P. Lerer
中科院分区：
文献类型：
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作者：
R. J. Lerer;M. P. Lerer
在 27 名患有轻微脑功能障碍的青少年中，有 16 名在经过 60 天的哌醋甲酯（利他林）试验后显示出主观和客观的改善证据。这些患者的积极客观变化表现在家长和老师完成康纳斯简略教师评定量表所记录的行为改善、本德格式塔测试表现的改善以及学业成绩的改善。主观改善包括提高注意力和集中注意力的能力以及减少焦虑和紧张症状。回顾性地没有确定具体的参数，这些参数对于预测哪些脑功能障碍轻微的青少年更有可能对哌醋甲酯治疗表现出积极反应具有价值。这些发现表明，哌醋甲酯治疗试验可能对有多动史的成绩不佳的青少年有帮助。
Sixteen of 27 adolescents with minimal brain dysfunction showed subjective and objective evidence of improvement following a 60-day trial of methylphenidate (Ritalin). Positive objective changes were demonstrated in these patients by improvement in behavior as recorded by parents and teachers completing the Conners' Abbreviated Teacher Rating Scale, by improvement in performance on the Bender-Gestalt Test, and by improvement in academic achievement. Subjective improvement included increased ability to attend and to concentrate and decreased symptoms of anxiety and nervousness. No specific parameters were identified retrospectively which could have been of value in predicting which adolescents with minimal brain dysfunction were more likely to exhibit positive responses to methylphenidate therapy. These findings demonstrate that a trial of methylphenidate therapy may prove helpful for underachieving adolescents with a documented history of hyperactivity.