Mortality and causes of death in Dutch haemophiliacs, 1973–86
Mortality and causes of death in Dutch haemophiliacs, 1973–86
复制标题
荷兰血友病患者的死亡率和死因，1973-86
DOI：
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发表时间：
1989
影响因子：
6.5
通讯作者：
E. Briët
中科院分区：
文献类型：
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作者：
F. Rosendaal;I. Varekamp;C. Smit;A. Bröcker;H. Dijck;J. Vandenbroucke;J. Hermans;T. Suurmeijer;E. Briët
计算了1973年至1986年期间717名荷兰血友病患者的死亡率。平均随访10.9年;无患者失访。通过精算方法和患者年分析将数据与一般男性人群进行比较。43例患者死亡，而在相同年龄分布的假设非血友病患者组中预计有20例死亡。因此，总死亡率比一般人群高2.1倍。这导致计算出的预期寿命为66岁，而一般男性人口的预期寿命为74岁。血友病的严重程度对死亡率没有太大影响。观察到预防对寿命可能有益的影响。出血发生在所有死亡的一半，其中创伤性出血是最普遍的。由于缺血性心脏病导致的死亡人数显著低于预期（减少80%），因此作者得出结论，血友病可预防缺血性心脏病。癌症死亡率明显高于预期（2.5倍）。
Mortality figures were calculated for a group of 717 Dutch haemophiliacs over the period 1973‐86. Follow‐up was on average 10.9 years; no patients were lost to follow‐up. The data were compared to the general male population by actuarial methods and patient‐year analysis. Forty‐three patients died, while 20 deaths were expected in a hypothetical group of non‐haemophiliacs of the same age distribution. Hence, overall mortality was 2.1 times higher than in the general population. This leads to a calculated life expectancy of 66 years, as compared to 74 years in the general male population. Mortality did not differ much by severity of haemophilia. A possibly beneficial effect of prophylaxis on longevity was observed. Haemorrhage occurred in half of all deaths and among these traumatic bleeding was the most prevalent. The number of deaths due to ischaemic heart disease was significantly lower (80% reduction) than expected and therefore the authors conclude that haemophilia offers protection against ischaemic heart disease. Cancer mortality was significantly higher (2.5 times) than expected.
用因子浓缩物治疗的血友病受试者出现迟发性皮肤超敏反应。
DOI：
10.1016/0002-9343(86)90545-0
发表时间：
1986
期刊：
The American journal of medicine
影响因子：
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作者：
Brettler,DB;Forsberg,AD;Brewster,F;Sullivan,JL;Levine,PH
通讯作者：
Levine,PH