Vitamin D Serum Levels and Markers of Asthma Control in Italian Children
Vitamin D Serum Levels and Markers of Asthma Control in Italian Children
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DOI：
10.1016/j.jpeds.2010.08.043
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发表时间：
2011-03-01
影响因子：
5.1
通讯作者：
Boner, Attilio L.
中科院分区：
文献类型：
--
作者：
Chinellato, Iolanda;Piazza, Michele;Boner, Attilio L.
目的探讨血清维生素D（25-hydroxycholecalciferol，25（OH）D）水平与儿童哮喘控制的关系。研究设计我们研究了75名哮喘儿童25-hydroxycholecalciferol [25（OH）D]浓度与基线肺功能和哮喘控制水平的关系，根据全球哮喘倡议指南和儿童哮喘控制测试进行评估（年龄范围5-11岁; 43名男性）在冬季和早春进行的横断面研究中。结果只有9.4%的儿童有足够的血清25（OH）D（至少30 - 40 ng/mL）。用力肺活量百分比预测值与血清25（OH）D之间存在显著正相关（r = 0.25，P = 0.040）。1秒用力呼气量也是如此，尽管没有统计学显著性（r = 0.16，P = 0.157）。哮喘控制良好的受试者血清25（OH）D水平高于哮喘部分控制或未控制的儿童，中位数分别为22.2（16.3; 25.4）、17.8（11.8; 22.1）和18.1（15.0; 18.5）（P = 0.023）。此外，25（OH）D和儿童哮喘控制测试（r = 0.28; P = 0.011）。结论我们的研究结果表明，维生素D缺乏症是常见的儿童哮喘生活在地中海国家。在这些儿童中，维生素D水平较低与哮喘控制能力下降有关。（J Pediatr 2011;158：437-41）。
Objective To establish the relationship between vitamin D serum levels, pulmonary function, and asthma control in children.Study design We studied the relationship between 25-hydroxy cholecalciferol [25(OH) D] concentrations and baseline spirometry and levels of asthma control, assessed according to Global Initiative for Asthma guidelines and the Childhood Asthma Control Test, in 75 children with asthma (age range 5-11 years; 43 males) in a cross-sectional study carried out during the winter and early spring.Results Only 9.4% of our children had a sufficient serum25(OH) D (at least 30 to 40 ng/mL). A significant positive correlation was found between forced vital capacity percent predicted and serum 25(OH) D (r = 0.25, P = .040). This was true also for forced expiratory volume in 1 second, even though it was not statistically significant (r = 0.16, P = .157). Subjects with well-controlled asthma had higher serumlevels of 25(OH) D than children with partially controlled or non-controlled asthma, with values of (median [Q1; Q3]) 22.2 (16.3; 25.4), 17.8 (11.8; 22.1) and 18.1 (15.0; 18.5), respectively (P = .023). Furthermore, a positive correlation was found between 25(OH) D and the Childhood Asthma Control Test (r = 0.28; P = .011).Conclusions Our results indicate that hypovitaminosis D is frequent in children with asthma living in a Mediterranean country. In those children, lower levels of vitamin D are associated with reduced asthma control. (J Pediatr 2011;158:437-41).