Regulation of lipolysis: natriuretic peptides and the development of cachexia
Regulation of lipolysis: natriuretic peptides and the development of cachexia
复制标题
DOI：
10.1016/s0167-5273(02)00241-3
复制
发表时间：
2002-09-01
影响因子：
3.5
通讯作者：
Tigas, S
中科院分区：
文献类型：
--
作者：
Kalra, PR;Tigas, S
恶病质的发展在许多病理状态中常见，并且与显著受损的预后相关。在这种情况下，脂肪组织的损失似乎具有特殊的病理生理学意义。脂解在健康中受到密切调节;主要的既定途径涉及儿茶酚胺（刺激脂解）和胰岛素（抑制脂解）。恶病质中的消耗过程与显著的代谢功能障碍和这种严密的调节控制的丧失有关。利钠肽是一类具有重要的血管舒张、利钠和利尿特性的相关肽。最近已经表明，利钠肽也是人体脂解的有效刺激物。在这方面，心房肽和脑钠肽似乎具有最大的脂解作用，并且在效力上与儿茶酚胺相似。在几种病理状态下发现循环利钠肽水平升高，通常反映疾病的严重程度。这篇文章将提供一个简明扼要的审查，在人类脂解的调节，集中在利钠肽的作用。将讨论利钠肽与恶病质发展的相关性。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The development of cachexia is commonly seen in many pathological states and is associated with a markedly impaired prognosis. Loss of fat tissue appears to be of particular pathophysiological importance in this setting. Lipolysis is closely regulated in health; the major established pathways involving catecholamines (stimulation of lipolysis) and insulin (inhibition of lipolysis). The wasting process in cachexia is associated with marked metabolic dysfunction, and loss of this tight regulatory control. Natriuretic peptides are a family of related peptides with important vasodilatory, natriuretic and diuretic properties. It has recently been shown that natriuretic peptides are also potent stimuli for lipolysis in humans. In this respect, atrial and brain natriuretic peptide appear to have the greatest lipolytic effect, and are similar in potency to catecholamines. Elevated levels of circulating natriuretic peptides are found in several pathological states, and generally reflect disease severity. This article will provide a concise review of the regulation of lipolysis in humans, concentrating on the role of the natriuretic peptides. The relevance of natriuretic peptides to the development of cachexia will be discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.