The host interactome of influenza virus presents new potential targets for antiviral drugs.
The host interactome of influenza virus presents new potential targets for antiviral drugs.
复制标题
流感病毒的宿主相互作用介绍了抗病毒药的新潜在靶标。
DOI：
10.1002/rmv.703
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发表时间：
2011-11
影响因子：
11.1
通讯作者：
Shaw, Megan L.
中科院分区：
文献类型：
--
作者：
Shaw, Megan L.
抗病毒药物耐药性的增加是治疗流感的主要问题，特别是在保护性疫苗的可用性不确定的大流行环境中。针对病毒蛋白质和小RNA病毒的药物的耐药性通常是一个问题;也有有限数量的病毒蛋白质可以被小分子抑制。一种正在获得支持的新方法是，可以将促进病毒复制的细胞蛋白质用作替代靶点。针对病毒蛋白的药物往往具有病毒特异性，而针对宿主靶点的药物具有广谱抗病毒活性的潜力，因为许多病毒可能共同依赖于该宿主功能。对于流感病毒，我们对哪些细胞因子参与病毒复制的知识非常有限，更不用说这些细胞因子中哪些具有合适的特性作为药物靶点。通过使用高通量RNA干扰筛选，一些研究已经解决了我们知识中的这一空白。由此产生的数据集提供了对参与流感病毒复制周期的宿主途径的新见解，并确定了这些途径中可能作为未来抗病毒药物开发潜在靶点的特定宿主因子。版权所有© 2011约翰威利父子有限公司.
Increasing antiviral drug resistance is a major concern for treating influenza, especially in a pandemic setting when the availability of a protective vaccine is uncertain. Resistance is often an issue with drugs directed at viral proteins and for small RNA viruses; there are also a limited number of viral proteins that are amenable to inhibition by a small molecule. A new approach that is gaining support is that cellular proteins, which facilitate virus replication, may be used as alternative targets. Whereas drugs directed at viral proteins tend to be virus‐specific, drugs directed at host targets have the potential to have broad‐spectrum antiviral activity as many viruses may share a dependency on that host function. For influenza virus, we have very limited knowledge of which cellular factors are involved in virus replication, let alone which of these have suitable properties to serve as drug targets. Through the use of high‐throughput RNA interference screens, several studies have addressed this gap in our knowledge. The resulting datasets provide new insight into host pathways that are involved in the influenza virus replication cycle and identify specific host factors in these pathways that may serve as potential targets for future antiviral drug development. Copyright © 2011 John Wiley & Sons, Ltd.
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DOI：
10.1093/cid/cir001
发表时间：
2011-03-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Hernandez JE;Adiga R;Armstrong R;Bazan J;Bonilla H;Bradley J;Dretler R;Ison MG;Mangino JE;Maroushek S;Shetty AK;Wald A;Ziebold C;Elder J;Hollister AS;Sheridan W;eIND Peramivir Investigators
通讯作者：
eIND Peramivir Investigators
影响因子：
5.4
作者：
GUINEA, R;CARRASCO, L
通讯作者：
CARRASCO, L
影响因子：
168.9
作者：
Gubareva, LV;Kaiser, L;Hayden, FG
通讯作者：
Hayden, FG
DOI：
10.1126/science.1187816
发表时间：
2010-06-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bloom JD;Gong LI;Baltimore D
通讯作者：
Baltimore D
影响因子：
64.8
作者：
Dias, Alexandre;Bouvier, Denis;Ruigrok, Rob W. H.
通讯作者：
Ruigrok, Rob W. H.