The α1D-adrenergic receptor modulates cardiovascular and drinking responses to central salt loading in mice
The α1D-adrenergic receptor modulates cardiovascular and drinking responses to central salt loading in mice
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DOI：
10.1016/j.neulet.2003.11.014
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发表时间：
2004-02-06
影响因子：
2.5
通讯作者：
Kannan, H
中科院分区：
文献类型：
--
作者：
Chu, CP;Kunitake, T;Kannan, H
为了表征特定 α-肾上腺素能受体 (α(1)-AR) 亚型与高血压的关系，在 α(1D)-AR 缺陷小鼠（基因敲除）中研究了与中枢盐或血管紧张素 II (ANG II) 诱导的高血压相关的参数。 α(1D)(-/-) 小鼠的基线每日水摄入量和食物摄入量大于 α(1D)(+/+) 小鼠。与 α(1D)(+/+) 小鼠相比，脑室内 (i.c.v.) 注射 NaCl（0.67 M NaCl，1 μl）后，α(1D)(-/-) 小鼠的平均动脉血压 (MABP)、心率和饮水量增加幅度较小。 I.c.v.给予ANG II (10 pmol)导致MABP和水摄入量增加，这在α(1D)(-/-)小鼠和α(1D)(+/+)小鼠中相似。这些结果表明，α(1D)-AR 至少部分参与中枢盐诱导的高血压和水摄入，但与 ANG II 诱导的高血压和水摄入无关。 (C) 2003 Elsevier Ireland Ltd. 保留所有权利。
To characterize the involvement of specific at-adrenergic receptor (alpha(1)-AR) subtypes in hypertension, parameters related to central salt- or angiotensin II (ANG II)-induced hypertension were investigated in alpha(1D)-AR-deficient mice (knockout). Baseline daily water intake and food intake were larger in alpha(1D)(-/-) mice than in alpha(1D)(+/+) mice. Intracerebroventricular (i.c.v.) administration of NaCl (0.67 M NaCl, 1 mul) elicited smaller increases in mean arterial blood pressure (MABP), heart rate, and water intake in alpha(1D)(-/-) mice than it did in alpha(1D)(+/+) mice. I.c.v. administration of ANG II (10 pmol) resulted in increases in MABP and water intake that were similar in alpha(1D)(-/-) mice and alpha(1D)(+/+) mice. These results suggest that alpha(1D)-AR is, at least in part, involved in central salt-induced but not ANG II-induced hypertension and water intake. (C) 2003 Elsevier Ireland Ltd. All rights reserved.