Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children
Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children
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DOI：
10.1016/j.bandc.2011.09.006
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发表时间：
2011-12-01
影响因子：
2.5
通讯作者：
D'Angiulli, Amedeo
中科院分区：
文献类型：
--
作者：
Calderon-Garciduenas, Lilian;Engle, Randall;D'Angiulli, Amedeo
暴露在严重的空气污染中会导致儿童的神经炎症和脑部结构性改变。我们测试了大脑发育模式、认知缺陷和白质高强度(WMH)是否与暴露在严重空气污染中有关。收集了20名墨西哥城(MC)儿童(10名有白质高信号，WMH+，10名无WMH-)和10名来自低污染城市的匹配对照组(CTL)的全球和局部脑MRI容量、认知能力(WISC-R)和血清炎症介质的基线和1年随访测量。CTL儿童和MC儿童的脑白质体积有显著差异--WMH+和WMH+--在右侧顶叶和双侧颞区。与CTL儿童相比，WMH-R和WMH+MC儿童在WISC-R词汇和数字广度分测验上都表现出进行性的缺陷。高度暴露的儿童的认知缺陷与在一年的随访中检测到的体积差异的定位相匹配，因为观察到的缺陷与顶叶和颞叶功能的损害是一致的。尽管存在前额叶WMH，但与CTL儿童相比，墨西哥城儿童在各种认知测试中的表现更差，因此WMH+可能只能部分识别潜在的白质病理。总而言之，这些发现揭示了暴露在空气污染中可能扰乱大脑发育的轨迹，并导致儿童时期的认知障碍。(C)2011 Elsevier Inc.保留所有权利。
Exposure to severe air pollution produces neuroinflammation and structural brain alterations in children. We tested whether patterns of brain growth, cognitive deficits and white matter hyperintensities (WMH) are associated with exposures to severe air pollution. Baseline and 1 year follow-up measurements of global and regional brain MRI volumes, cognitive abilities (Wechsler Intelligence Scale for Children-Revised, WISC-R), and serum inflammatory mediators were collected in 20 Mexico City (MC) children (10 with white matter hyperintensities, WMH+, and 10 without, WMH-) and 10 matched controls (CTL) from a low polluted city. There were significant differences in white matter volumes between CTL and MC children - both WMH+ and WMH- - in right parietal and bilateral temporal areas. Both WMH- and WMH+ MC children showed progressive deficits, compared to CTL children, on the WISC-R Vocabulary and Digit Span subtests. The cognitive deficits in highly exposed children match the localization of the volumetric differences detected over the 1 year follow-up, since the deficits observed are consistent with impairment of parietal and temporal lobe functions. Regardless of the presence of prefrontal WMH, Mexico City children performed more poorly across a variety of cognitive tests, compared to CTL children, thus WMH+ is likely only partially identifying underlying white matter pathology. Together these findings reveal that exposure to air pollution may perturb the trajectory of cerebral development and result in cognitive deficits during childhood. (C) 2011 Elsevier Inc. All rights reserved.