Alteration of lipid parameters in patients with subclinical hypothyroidism.
Alteration of lipid parameters in patients with subclinical hypothyroidism.
复制标题
亚临床甲状腺功能减退症患者的脂质参数改变。
DOI：
10.5812/ijem.17496
复制
发表时间：
2014-07
影响因子：
2.1
通讯作者：
Kumar Kotwal S
中科院分区：
文献类型：
--
作者：
Laway BA;War FA;Shah S;Misgar RA;Kumar Kotwal S
显性甲状腺功能减退症与脂质代谢异常有关，但关于亚临床甲状腺功能减退症（SCH）的脂质变化程度存在相互矛盾的结果。本研究的目的是评估印度北部人群中有和没有SCH的受试者之间血脂参数的差异。采用横断面研究方法，对70例亚临床甲状腺功能减退症患者和100例年龄、性别相匹配的甲状腺功能正常者的血脂指标进行了评价。SCH组血清总胆固醇（TC）、甘油三酯（TG）和极低密度胆固醇（VLDL）水平显著高于对照组（P < 0.05）。血清促甲状腺激素（TSH）大于10 mU/L的患者的TC、TG和低密度胆固醇（LDL）浓度高于血清TSH等于或小于10 mU/L的患者，但差异无统计学意义。血清高密度胆固醇（HDL-C）浓度与血清TSH水平无相关性。SCH患者TC、TG、VLDL均升高。
Overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) exist. The aim of this study was to assess differences in lipid profile parameters between subjects with and without SCH in a north Indian population. Serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study. Mean serum total cholesterol (TC), triglycerides (TG) and very low-density cholesterol (VLDL) were significantly higher in patients with SCH than controls (P < 0.05). Mean TC, TG and low-density cholesterol (LDL) concentrations were higher in patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L than those with serum TSH equal to or less than 10 mU/L, but this difference was not statistically significant. No association was found between serum high-density cholesterol (HDL-C) concentration and serum TSH level. High TC, TG and VLDL were observed in our patients with SCH.