Regulation of maternal behavior and offspring growth by paternally expressed Peg3
Regulation of maternal behavior and offspring growth by paternally expressed Peg3
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DOI：
10.1126/science.284.5412.330
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发表时间：
1999-04-09
期刊：
影响因子：
56.9
通讯作者：
Surani, MA
中科院分区：
文献类型：
--
作者：
Li, LL;Keverne, EB;Surani, MA
印记基因显示出依赖于亲本来源的单等位基因表达，其明显地调节复杂的哺乳动物性状，包括生长和行为。Peg3基因在胚胎和成年大脑中仅从父系等位基因表达。Peg3基因的突变导致生长迟缓，以及母亲行为的显著损害，经常导致后代死亡。这一结果可能部分是由于神经元连接缺陷，以及下丘脑催产素神经元减少，因为突变的母亲缺乏乳汁排出。这项研究提供了进一步的见解，在调节哺乳动物的生长和行为的印记基因剂量的表观遗传调控的演变。
Imprinted genes display parent-of-origin-dependent monoallelic expression that apparently regulates complex mammalian traits, including growth and behavior. The Peg3 gene is expressed in embryos and the adult brain from the paternal allele only. A mutation in the Peg3 gene resulted in growth retardation, as well as a striking impairment of maternal behavior that frequently resulted in death of the offspring. This result may be partly due to defective neuronal connectivity, as well as reduced oxytocin neurons in the hypothalamus, because mutant mothers were deficient in milk ejection. This study provides further insights on the evolution of epigenetic regulation of imprinted gene dosage in modulating mammalian growth and behavior.