Pulmonary Artery Enlargement Is Associated with Exacerbations and Mortality in Ever-Smokers with Preserved Ratio Impaired Spirometry.
Pulmonary Artery Enlargement Is Associated with Exacerbations and Mortality in Ever-Smokers with Preserved Ratio Impaired Spirometry.
复制标题
肺动脉扩张与肺量计保留比率受损的吸烟者的病情加重和死亡率相关。
DOI：
10.1164/rccm.202103-0619le
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发表时间：
2021
影响因子：
24.7
通讯作者：
Wells,JMichael
中科院分区：
文献类型：
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作者：
Wade,RChad;Simmons,JPatrick;Boueiz,Adel;Gregory,Andrew;Wan,EmilyS;Regan,ElizabethA;Bhatt,SuryaP;Han,MeiLanK;Bowler,RussellP;Crapo,JamesD;Silverman,EdwinK;Washko,GeorgeR;Dransfield,MarkT;Wells,JMichael
研究人群包括COPD基因（COPD遗传流行病学研究）的参与者，他们完成了全面的临床病史、生活质量问卷，包括圣乔治呼吸问卷（SGRQ）、支气管扩张剂使用前后的肺功能测定和胸部CT扫描（7）。作为纵向随访计划的一部分，每隔6个月收集一次急性加重频率和死亡数据（8）。如果受试者呼吸困难、咳嗽或痰量增加需要治疗，则记录为呼吸加重。严重急性发作需要入院或急诊室治疗。通过随访计划和社会保障死亡指数获得生命状态。
MethodsThe study population includes participants in COPDGene (the Genetic Epidemiology of COPD Study) who completed comprehensive clinical history, quality of life questionnaires including St. George’s Respiratory Questionnaire (SGRQ), pre-and post-bronchodilator spirometry, and chest CT scans (7). Exacerbation frequency and death data were collected at 6-month intervals as part of a longitudinal follow-up program (8). Participants were recorded as having a respiratory exacerbation if they had increased dyspnea, cough, or sputum production requiring treatment. Severe exacerbations required admission to the hospital or emergency room for treatment. Vital status was obtained through the follow-up program and from the Social Security Death Index.