Camera-based Prospective Motion Correction in Paediatric Epilepsy Patients Enables EEG-fMRI Localization Even in High-motion States.
Camera-based Prospective Motion Correction in Paediatric Epilepsy Patients Enables EEG-fMRI Localization Even in High-motion States.
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DOI：
10.1007/s10548-023-00945-0
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发表时间：
2023-05
期刊：
影响因子：
2.7
通讯作者：
Carmichael, David W.
中科院分区：
文献类型：
--
作者：
Steinbrenner, Mirja;McDowell, Amy;Centeno, Maria;Moeller, Friederike;Perani, Suejen;Lorio, Sara;Maziero, Danilo;Carmichael, David W.
背景：EEG-fMRI是定位致痫带(EZ)的有用辅助检查，特别是在MRI阴性的病例中。然而，由于被摄体运动对MRI和EEG信号都有很大的影响，因此对被摄体运动提出了特别的挑战。传统上认为，功能磁共振成像的预期运动校正(PMC)排除了脑电伪影校正。方法：在大奥蒙德街医院接受手术前评估的儿童被纳入研究。功能磁共振成像的PMC是使用商业系统进行的，该系统带有Moiré相跟踪标记和MR兼容相机。对于回溯性EEG矫正，比较了标准EEG矫正和运动教育EEG伪影矫正(REEGMAS)。结果：10名儿童同时接受了EEG-fMRI检查。总体头部运动速度较高(平均均方根速度 <； 1.5 mm/S)，并表现出较高的个体间和个体内变异性。比较PMC摄像机测量的运动和通过重新排列fMRI图像检测到的(未校正的残余)运动，其预期校正后的运动减少了五分之一。使用标准方法和REEGMAS的回溯性脑电校正使生理性噪声和癫痫样放电得以可视化和识别。10名儿童中有7名有明显的MAP，其中6名符合临床EZ假说。结论：据我们所知，这是第一次在儿科临床环境中应用基于相机的PMC进行MRI。尽管有大量的运动，PMC结合回溯性脑电校正恢复了数据，并在受试者的高水平运动中获得了临床上有意义的结果。目前，实践上的限制可能会限制这项技术的广泛使用。网上版载有补充材料，可在10.1007/s10548-023-00945-0查阅。
Background: EEG-fMRI is a useful additional test to localize the epileptogenic zone (EZ) particularly in MRI negative cases. However subject motion presents a particular challenge owing to its large effects on both MRI and EEG signal. Traditionally it is assumed that prospective motion correction (PMC) of fMRI precludes EEG artifact correction. Methods: Children undergoing presurgical assessment at Great Ormond Street Hospital were included into the study. PMC of fMRI was done using a commercial system with a Moiré Phase Tracking marker and MR-compatible camera. For retrospective EEG correction both a standard and a motion educated EEG artefact correction (REEGMAS) were compared to each other. Results: Ten children underwent simultaneous EEG-fMRI. Overall head movement was high (mean RMS velocity < 1.5 mm/s) and showed high inter- and intra-individual variability. Comparing motion measured by the PMC camera and the (uncorrected residual) motion detected by realignment of fMRI images, there was a five-fold reduction in motion from its prospective correction. Retrospective EEG correction using both standard approaches and REEGMAS allowed the visualization and identification of physiological noise and epileptiform discharges. Seven of 10 children had significant maps, which were concordant with the clinical EZ hypothesis in 6 of these 7. Conclusion: To our knowledge this is the first application of camera-based PMC for MRI in a pediatric clinical setting. Despite large amount of movement PMC in combination with retrospective EEG correction recovered data and obtained clinically meaningful results during high levels of subject motion. Practical limitations may currently limit the widespread use of this technology. The online version contains supplementary material available at 10.1007/s10548-023-00945-0.
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