Progress on the GntR family transcription regulators in bacteria
Progress on the GntR family transcription regulators in bacteria
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DOI：
10.16288/j.yczz.20-245
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Lu, Guangtao
中科院分区：
文献类型：
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作者：
Liu, Guofang;Wang, Xinxin;Lu, Guangtao
在细菌中，GntR家族转录调节因子是广泛存在的转录因子家族。该家族的成员由两个功能结构域组成，一个是保守的N-末端DNA结合结构域，其含有典型的螺旋-转角-螺旋（HTH）基序，另一个是C-末端效应物结合或寡聚化结构域。通常，N-末端DNA结合结构域的氨基酸序列是高度保守的，但在C-末端效应物结合或寡聚化结构域中不同。在过去的几十年中，许多GntR家族的转录调控因子已被确定在许多细菌。这些调节因子控制多种细胞过程，例如细胞运动性、葡萄糖代谢、细菌抗性、致病性和毒力。本文就GntR家族转录调控因子的发现、C端结构域、生物学功能及调控方式等方面进行综述。本文对GntR家族转录调控因子的功能和作用机制进行了综述。
In bacteria, GntR family transcription regulators are the widespread family of transcription factors. Members of this family consist of two functional domains, a conserved N-terminal DNA-binding domain that contains a typical helix-turn-helix (HTH) motif and a C-terminal effector-binding or oligomerization domain. Usually, the amino acid sequences of N-terminal DNA-binding domains are highly conserved, but differ in the C-terminal effector-binding or oligomerization domains. In the past several decades, many GntR family transcription regulators have been characterized in a number of bacteria. These regulators control a variety of cellular processes such as cell motility, glucose metabolism, bacterial resistance, pathogenesis and virulence. In this review, we summarized the discovery, C-terminal domains, biological function and regulation mode of GntR family transcription regulators. This review will help researchers to obtain more knowledge about the functions and mechanisms of the GntR family transcriptional regulatory factors.