Computational model of TASK channels and PKC-pathway dependent serotonergic modulatory effects in respiratory-related neurons.
Computational model of TASK channels and PKC-pathway dependent serotonergic modulatory effects in respiratory-related neurons.
复制标题
呼吸相关神经元中 TASK 通道和 PKC 通路依赖的 5-羟色胺调节作用的计算模型。
DOI：
10.1007/978-0-387-73693-8_67
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发表时间：
2008
影响因子：
--
通讯作者：
Butera,RobertJ
中科院分区：
文献类型：
--
作者：
Tsao,Tzu-HsinB;Butera,RobertJ
Hypoglossal motoneurons (HMs) receive serotonergic innervations from medullary raphe neurons and produce rhythmic discharge patterns closely associated with respiratory rhythm generated in the pre-Bötzinger complex (pBC). HM activity is subject to modulation by numerous factors including serotonin (5-HT), TRH, norepinephrine (NE), substance P (SP), pH, multiple protein kinases and phosphatases. In this present work, we introduce a computational HM model that facilitates the investigation of how neuromodulatory factors. such as 5-HT and pH, can affect HM activities.
