Trimethoxysilyl end-capped hyperbranched polyglycidol/polycaprolactone copolymers for cell delivery and tissue repair: synthesis, characterisation and aqueous solution properties
Trimethoxysilyl end-capped hyperbranched polyglycidol/polycaprolactone copolymers for cell delivery and tissue repair: synthesis, characterisation and aqueous solution properties
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DOI：
10.1016/j.eurpolymj.2018.10.030
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发表时间：
2019-03-01
影响因子：
6
通讯作者：
Halacheva, Silvia S.
中科院分区：
文献类型：
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作者：
Gonzalez-Chomon, Clara;Garamus, Vasil M.;Halacheva, Silvia S.
合成了一种新型的PCL-HBPG/SiHBPG三嵌段共聚物，它由聚己内酯(PCL)核和两个三甲氧基硅基端端支化的超支化聚缩水甘油(HBPG/SiHBPG)组成，具有不同的相对分子质量。研究了不同温度下共聚物的组成和结构对结晶、熔融、热降解和水溶液行为的影响。在水溶液中，当浓度高于临界聚集浓度时，PCL-HBPG/SiHBPG共聚物很容易自组装成由PCL结构域和由HBPG/SiHBPG支链组成的电晕组成的大的多核结构。多核结构是通过HBPG部分的大量氢键以及硅氧烷交联键(即Si-O-Si键)的形成而稳定的。由于硅氧烷键的形成是不可逆的，基于PCL-HBPG/SiHBPG的颗粒将在体内以较高的浓度共价交联，形成可注射的凝胶支架，这种支架将具有生物相容性，并能够在不需要外部生物刺激的情况下诱导细胞附着和分化。
New PCL-HBPG/SiHBPG triblock copolymers composed of a polycaprolactone (PCL) core with two outer blocks of trimethoxysilyl end-capped hyperbranched polyglycidol (HBPG/SiHBPG), of varying molecular weight, have been successfully synthesised and characterised. The effect of copolymer composition and structure upon the crystallization, melting, thermal degradation and aqueous solution behaviour were investigated at various temperatures. In aqueous solution, at concentrations above their corresponding critical aggregation concentration the PCL-HBPG/SiHBPG copolymers readily self-assemble into large multicore structures composed of PCL domains and corona consisting of HBPG/SiHBPG branches. The multicore structures were stabilized by numerous hydrogen-bonds from the HBPG moieties as well as via formation of siloxane crosslinks (i.e. Si-O-Si bonds). As the formation of the siloxane linkages is irreversible the PCL-HBPG/SiHBPG-based particles will be covalently crosslinked at higher concentrations in vivo and form injectable gels scaffolds that will be biocompatible and capable of invoking cell attachment and differentiation without the need for exogenous biological stimuli.