Comparative Gene Expression Profiling of Olfactory Ensheathing Cells from Olfactory Bulb and Olfactory Mucosa

Comparative Gene Expression Profiling of Olfactory Ensheathing Cells from Olfactory Bulb and Olfactory Mucosa
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DOI：
10.1002/glia.21030
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发表时间：
2010-10-01
期刊：
GLIA
影响因子：
6.2
通讯作者：
Marie, Jean-Paul
Marie, Jean-Paul
中科院分区：
医学1区
文献类型：
--
作者：
Guerout, Nicolas;Derambure, Celine;Marie, Jean-Paul

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嗅鞘细胞（OEC）具有促进神经系统再生的能力。因此，它们有望用于细胞治疗。大多数的实验研究都是从嗅球（OB）中提取嗅鞘细胞来研究嗅鞘细胞的作用。然而，对于临床人类应用，嗅粘膜（OM）似乎是OEC的唯一可接受的来源。许多研究比较了OB和OM的OECs在神经系统损伤后改善功能性神经再生的不同能力。然而，两种OEC群体可能在几个方面存在差异，这可能影响体内移植后的所有命运。我们在这里报告的第一项研究，比较这两个人口的嗅鞘细胞之间的基因表达谱。OB-OECs和OM-OECs显示出不同的基因表达模式，这表明它们可能参与不同的生理过程。值得注意的是，OM-OECs过表达伤口愈合和细胞外基质调节的基因特征。相反，OB-OECs基因谱表明在神经系统发育中起着重要作用。因此，OB-OECs和OM-OECs在基因表达模式上存在根本性差异，这可能是未来临床应用的关键点。(C)2010 Wiley-Liss，Inc.
Olfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source for OECs. Many studies have compared the distinct ability of OECs from OB and OM to improve functional nerve regeneration after lesion of the nervous system. Nevertheless, the two populations of OECs may differ in several points, which might affect all fate after transplantation in vivo. We report here the first study which compares gene expression profiling between these two populations of OECs. It appears that OB-OECs and OM-OECs display distinct gene expression pattern, which suggest that they may be implicated in different physiological processes. Notably, OM-OECs overexpress genes characteristic of wound healing and regulation of extra cellular matrix. In contrast, OB-OECs gene profile suggests a prominent role in nervous system development. Hence, OB-OECs and OM-OECs fundamentally differ in their gene expression pattern, which may represent a crucial point for future clinical application. (C) 2010 Wiley-Liss, Inc.