Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering
Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering
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DOI：
10.1038/nbt.3358
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发表时间：
2015-10-01
影响因子：
46.9
通讯作者：
Van Der Straeten, Dominique
中科院分区：
文献类型：
--
作者：
Blancquaert, Dieter;Van Daele, Jeroen;Van Der Straeten, Dominique
主要作物的生物强化可以帮助缓解人类微量营养素缺乏。我们发现储存的米粒中的叶酸是不稳定的，这降低了叶酸生物强化的潜在效益。通过将叶酸与叶酸结合蛋白络合，我们获得了比野生型水稻高150倍的叶酸浓度，从而提高了叶酸的稳定性，从而使生物强化的高叶酸米粒能够长期储存。
Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains.