Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation
Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation
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多粘菌素治疗小儿神经外科术后广泛耐药菌颅内感染
DOI：
10.1007/s12519-020-00350-8
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发表时间：
2020-03
影响因子：
8.7
通讯作者：
Shu Qiang
中科院分区：
文献类型：
--
作者：
Ye Jing;Tan Lin-Hua;Shen Zhi-Peng;Yu Yun-Song;Lai Deng-Ming;Fan Jie;Shu Qiang
背景：广泛耐药杆菌引起的脑膜炎增加对抗生素的选择提出了重大挑战。本研究的目的是评估多粘菌素治疗儿童广泛耐药细菌引起的神经外科后脑膜炎的疗效和安全性。方法回顾性研究应用多粘菌素治疗≥3天的儿童广泛耐药菌所致神经外科术后脑膜炎病例。结果5例神经外科术后脑膜炎患儿中，鲍曼不动杆菌感染3例，肺炎克雷伯菌感染1例，铜绿假单胞菌感染1例。药敏试验显示它们是广泛耐药菌。2例患儿静脉注射多粘菌素e， 3例患儿静脉联合脑室注射多粘菌素b， 1例感染肺炎克雷伯菌，最终死于感染性休克。多粘菌素未见严重不良反应。结论多粘菌素治疗小儿神经外科术后多药耐药细菌性脑膜炎安全有效。
BackgroundIncreased meningitis caused by extensively drug-resistant bacillary presents a significant challenge in antibiotic selection. The aim of our study was to evaluate the efficacy and safety of polymyxin in the treatment of post-neurosurgical meningitis due to the extensively drug-resistant bacillary in children.MethodsWe performed a retrospective study on post-neurosurgical meningitis caused by the extensively drug-resistant bacillary in children, who were treated with polymyxin for ≥ 3 days.ResultsAmong five post-neurosurgical meningitis cases that were included, the children were infected byAcinetobacter baumannii(n= 3),Klebsiella pneumonia(n= 1), andPseudomonas aeruginosa(n= 1). The drug susceptibility test showed that they were extensively drug-resistant bacillary. Two patients received intravenous polymyxin E. Three children received intravenous combined with intraventricular injection of polymyxin B. One patient infected byKlebsiella pneumoniaeventually died of septic shock. No serious adverse effects of polymyxin were observed.ConclusionsPolymyxin is a safe and effective therapy for post-neurosurgical, multidrug-resistant bacillary meningitis in children.
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DOI：
--
发表时间：
2007-06
期刊：
Neuro endocrinology letters
影响因子：
--
作者：
A. Ondrušová;E. Kalavsky;B. Rudinský;F. P. Freybergh;F. Bauer;J. Miklosko;M. Huttová;P. Kisac;R. Cauda
通讯作者：
A. Ondrušová;E. Kalavsky;B. Rudinský;F. P. Freybergh;F. Bauer;J. Miklosko;M. Huttová;P. Kisac;R. Cauda
影响因子：
14.2
作者：
Khawcharoenporn, T.;Apisarnthanarak, A.;Mundy, L. M.
通讯作者：
Mundy, L. M.
影响因子：
11.8
作者：
Tunkel, Allan R.;Hasbun, Rodrigo;Zunt, Joseph R.
通讯作者：
Zunt, Joseph R.
影响因子：
2
作者：
Wang, KW;Chang, WN;Lu, CH
通讯作者：
Lu, CH
影响因子：
28.2
作者：
Kasiakou, SK;Rafailidis, PI;Falagas, ME
通讯作者：
Falagas, ME