Hippocampal function in cognition
Hippocampal function in cognition
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DOI：
10.1007/s00213-004-1795-9
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发表时间：
2004-06-01
影响因子：
3.4
通讯作者：
Sweatt, JD
中科院分区：
文献类型：
--
作者：
Sweatt, JD
理由和目标。任何对精神分裂症认知障碍的考虑都很自然地导致了关于正常认知基础的细胞和分子机制的问题。这篇综述将描述海马中认知加工的细胞基础的新兴模型。方法和结果。这篇综述将描述几个实验室的结果，这些实验室已经使用在行为啮齿动物体内记录来探测海马在认知中的作用。这些令人兴奋的研究表明，海马体在一般信息处理中的作用比以前认识到的更广泛。这些最近的研究结果表明，海马参与了每分钟的认知处理，包括空间信息处理，时间排序，并制定了环境中的对象之间的关系。结论.海马似乎在汇集环境信号并在空间和时间域中产生有凝聚力和统一的感知方面发挥着重要作用。海马体在认知中作用的新观点与精神分裂症模型非常吻合，该模型假设海马体功能障碍是精神分裂症患者认知能力下降的原因之一。
Rationale and objectives. Any consideration of cognitive disruption in schizophrenia quite naturally leads to questions concerning the cellular and molecular mechanisms underlying normal cognition. This review will describe emerging models for the cellular basis of cognitive processing in the hippocampus. Methods and results. This review will describe results from several laboratories that have used in vivo recording in behaving rodents to probe the role of the hippocampus in cognition. These exciting studies have indicated a broader role of the hippocampus in general information processing than was previously appreciated. These recent results suggest that the hippocampus is involved in minute-to-minute cognitive processing including spatial information processing, temporal sequencing, and formulating the relationships between objects in the environment. Conclusions. The hippocampus appears to play a major role in bringing together environmental signals and producing a cohesive and unified percept in the spatial and temporal domains. This new view of the role of the hippocampus in cognition fits strikingly well with models for schizophrenia hypothesizing hippocampal dysfunction as one cause of cognitive decline in schizophrenic patients.