Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome
Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome
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DOI：
10.1016/j.fertnstert.2004.11.080
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发表时间：
2005-06-01
影响因子：
6.7
通讯作者：
Heinonen, S
中科院分区：
文献类型：
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作者：
Jääskeläinen, J;Korhonen, S;Heinonen, S
目的：确定雄激素受体 (AR) 基因的 CAG 重复长度是否与多囊卵巢综合征 (PCOS) 易感性的个体差异有关。设计：回顾性病例对照研究。地点：大学诊所。患者：106 名患有 PCOS 的非糖尿病女性和 112 名不育的对照者。干预措施（S）：分析女性中的雄激素受体基因 CAG 重复长度主要结果指标：两组中雄激素受体基因 CAG 重复长度。结果 (S)：两组中平均 CAG(n) 均为 21.5 次重复（NS；t 检验）。此外，当 CAG(n) 长度分为三类 (CAG(n) = 25）时，两组的分布相似（NS；X-2 检验）。然而，所有五名妇女都携带
Objective: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS).Design: Retrospective case-control study.Setting: University-based clinic.Patient(s): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls.Intervention(S): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls.Main Outcome Measure(s): Androgen receptor gene CAG repeat length in both groups.Result(S): The mean CAG(n) was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAG(n) lengths were divided into three categories (CAG(n) = 25), the distribution was similar in both groups (NS; X-2 test). However, all five women carrying