Design and self-assembly of two-dimensional DNA crystals
Design and self-assembly of two-dimensional DNA crystals
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DOI：
10.1038/28998
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发表时间：
1998-08-06
期刊：
影响因子：
64.8
通讯作者：
Seeman, NC
中科院分区：
文献类型：
--
作者：
Winfree, E;Liu, FR;Seeman, NC
分子自组装提供了一种“自下而上”的方法来制造纳米级精度的物体。 DNA 分子结构和分子间相互作用特别适合复杂分子物体的设计和合成。我们报告了由合成 DNA 双交叉分子自组装而成的二维 DNA 晶体形式的设计和观察。结构单元之间的分子间相互作用是通过“粘性末端”的设计来编程的，“粘性末端”根据沃森-克里克互补性进行关联，使我们能够在纳米尺度上创建特定的周期性模式。图案化的晶体已通过原子力显微镜观察到。
Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.