Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels.
Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels.
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DOI：
10.1097/psy.0b013e318188a01e
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发表时间：
2008-10
影响因子：
3.3
通讯作者：
Spertus JA
中科院分区：
文献类型：
--
作者：
Amin AA;Menon RA;Reid KJ;Harris WS;Spertus JA
确定急性冠状动脉综合征（ACS）患者的膜二十碳五烯酸（EPA）+二十二碳六烯酸（DHA）水平（omega-3指数）与抑郁症的相关程度。抑郁与ACS患者心血管（CV）结局恶化相关。血细胞膜omega-3（n-3）脂肪酸（FAs）水平降低是CV疾病和抑郁症的一个新风险因素，可能有助于解释抑郁症和不良CV结局之间的联系。我们测量了759例确诊ACS患者的膜FA组成。分析不仅包括EPA和DHA，还包括n-6脂肪酸亚油酸和花生四烯酸（LA和AA）。抑郁症状的测量与患者健康问卷-9（PHQ）。多变量线性回归用于调整人口统计学和临床特征。在完全校正的模型中，n-3指数和抑郁症状（PHQ）之间存在显著的负相关关系（p = 0.034）。n-3指数每上升4.54%，抑郁症状就会下降1个百分点。与n-3脂肪酸相反，n-6脂肪酸LA和AA的膜水平在抑郁和非抑郁ACS患者之间没有差异。我们发现ACS患者的n-3指数与抑郁症状的患病率呈负相关。因此，本研究支持以下假设：n-3 FA组织水平降低是抑郁症和不良CV结局之间常见且可能可改变的联系。
To determine the extent to which levels of membrane eicosapentaenoic (EPA)+docosahexaenoic acids (DHA) (the omega-3 index) were associated with depression in patients with acute coronary syndrome (ACS). Depression is associated with worse cardiovascular (CV) outcomes in patients with ACS. Reduced levels of blood cell membrane omega-3 (n-3) fatty acids (FAs), an emerging risk factor for both CV disease and depression, may help to explain the link between depression and adverse CV outcomes. We measured membrane FA composition in 759 patients with confirmed ACS. The analysis included not only EPA and DHA but also the n-6 FAs linoleic and arachidonic acids (LA and AA). Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ). Multivariable linear regression was used to adjust for demographic and clinical characteristics. There was a significant inverse relationship between the n-3 index and depressive symptoms (PHQ) in the fully adjusted model (p = .034). For every 4.54% point rise in the n-3 index, there was a 1-point decline in depressive symptoms. In contrast to the n-3 FAs, membrane levels of the n-6 FAs LA and AA were not different between depressed and nondepressed ACS patients. We found an inverse relationship between the n-3 index and the prevalence of depressive symptoms in patients with ACS. Therefore, this study supports the hypothesis that reduced n-3 FA tissue levels are a common and potentially modifiable link between depression and adverse CV outcomes.