Beyond a motor disorder: A prospective evaluation of sleep quality in cervical dystonia
Beyond a motor disorder: A prospective evaluation of sleep quality in cervical dystonia
复制标题
DOI：
10.1016/j.parkreldis.2014.01.004
复制
发表时间：
2014-04-01
影响因子：
4.1
通讯作者：
Comella, Cynthia L.
中科院分区：
文献类型：
--
作者：
Eichenseer, Sheila R.;Stebbins, Glenn T.;Comella, Cynthia L.
背景：颈性肌张力障碍(CD)患者的睡眠障碍，尤其是与运动症状的关系，目前知之甚少。考虑到对生活质量的影响，澄清这些要点是至关重要的。方法：包括接受肉毒毒素(BoNT)注射的原发CD患者和年龄和性别匹配的健康对照组。在两组中，都评估了睡眠质量和日间困倦。在CD中，在注射BONT后重复这些评估。结果：共纳入54例CD患者和55例正常对照。与对照组相比，CD组睡眠质量受损的发生率更高(t=4.82p<；0.0005)，即使在控制了抑郁、焦虑和苯二氮卓类药物的影响后(F=5.62p=0.020)。两组间白天过度嗜睡的差异无统计学意义(t=1.67，p=0.1)。48例患者接受了BONT治疗，并进行了随访。在睡眠质量(t=0.834，p=0.41)和日间嗜睡(t=1.77，p=0.083)方面没有改善，尽管CD的严重程度(t=4.77，p<；0.0005)得到了改善。对健康的影响略有改善(t=2.10，p=0.04)。结论：CD患者的睡眠质量比健康受试者更严重，尽管CD的严重程度有了明显的改善，但经BONT治疗后，睡眠质量并没有改善。这种二分法表明，CD的睡眠障碍需要单独的焦点才能有效地治疗，不能被视为这种情况下运动因素的继发性并发症。爱思唯尔有限公司出版。
Background: Little is known about sleep disturbances in cervical dystonia (CD), particularly the relationship to motoric symptoms. It is critical to clarify these points given the impact on quality of life.Methods: Primary CD patients receiving botulinum toxin (BoNT) injections and age- and gender-matched healthy controls were included. In both groups, sleep quality and daytime sleepiness were assessed. In CD, these assessments were repeated following BoNT injections. CD severity, mood symptoms, and health impact of CD were also assessed.Results: 54 CD patients and 55 controls were included. Impaired sleep quality was more frequent in CD compared to controls (t = 4.82, p < 0.0005), even when controlling for the effects of depression, anxiety, and benzodiazepineuse (F = 5.62, p = 0.020). Excessive daytime sleepiness was not significantly different between groups (t = 1.67, p = 0.1). 48 patients received BoNT and returned for follow-up. There was no improvement in sleep quality (t = 0.834, p = 0.41) or daytime somnolence (t = 1.77, p = 0.083) despite improvement in CD severity (t = 4.77, p < 0.0005) with BoNT. There was a small improvement in health impact (t = 2.10, p = 0.04).Conclusion: Sleep quality was more impaired in CD patients, compared to healthy subjects, and did not improve following BoNT treatment, despite a robust improvement in CD severity. This dichotomy suggests that sleep aberrations in CD require separate focus for effective treatment and cannot be viewed as secondary complications of the motor elements of this condition. Published by Elsevier Ltd.