Comparative increases of lead and barium with age in human tooth enamel, rib and ulna.
Comparative increases of lead and barium with age in human tooth enamel, rib and ulna.
复制标题
人类牙釉质、肋骨和尺骨中铅和钡的含量随着年龄的增长而相对增加。
DOI：
10.1016/0048-9697(91)90259-h
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Erel,Y
中科院分区：
文献类型：
--
作者：
Manea-Krichten,M;Patterson,C;Miller,G;Settle,D;Erel,Y
6名67-96岁的现代人死后牙釉质、肋骨和尺骨中的铅和钡。80)在三种不同类型的骨组织中，随着年龄的增长，Pb/Ca（wt）在肋骨、尺骨和牙釉质中的累积量相似：Pb/Ca（wt）分别为3.0、5.2和3.9 × 10− 5; Ba/Ca（wt）分别为2.4、2.4和1.8 × 10− 5。肋骨（灰）、尺骨（灰）和釉质（干）中铅的平均浓度分别为11、19和14 μg g− 1。在肋骨（灰）、尺骨（灰）和釉质（干）中，钡的平均值分别为8.7、8.9和6.4 μg g g− 1。将我们80岁受试者尺骨中的钡与其他研究者在当代年轻人群骨骼中测定的钡进行比较，发现钡随年龄的积累速度约为骨骼中铅积累速度的一半。Ba在肋骨，尺骨和釉质中的浓度呈正相关，在一个人内相似，但在门静脉血中吸收吸收的变化成比例的受试者之间的变化。钡可以从血牙本质源扩散到牙釉质中，在牙釉质中钡取代Ca并随着年龄积累。由于80岁以上受试者铅污染严重，且铅摄入量随年龄变化，牙釉质铅与骨铅的相关性较Ba更为分散。铅稳定同位素示踪表明：（1）在三种骨组织中，铅在牙釉质中的停留时间最长，随年龄的增长，铅在牙釉质中以扩散方式积累，交换损失较少;铅在致密尺骨中的停留时间比在骨小梁肋中的停留时间长，因为它伴随Ca从血液向骨的成骨细胞转移，然后从骨的成骨细胞转移回血液。
Lead and Ba in postmortem tooth enamel, rib and ulna of six contemporary people (67–96 years; ave. 80) were shown to exhibit similar accumulations with age in the three different types of osseous tissue: Pb/Ca (wt) = 3.0, 5.2, and 3.9 × 10−5in rib, ulna, and tooth enamel; and Ba/Ca (wt) = 2.4, 2.4, and 1.8 × 10−5in rib, ulna, and tooth enamel, respectively. Mean concentrations of Pb were 11, 19, and 14 μg g−1in rib (ash), ulna (ash), and enamel (dry), respectively. Means for Ba were 8.7, 8.9, and 6.4 μg g−1in rib (ash), ulna (ash), and enamel (dry), respectively.Comparison of Ba in ulna of our 80-year-old subjects with Ba determined by other investigators in bones of younger contemporary populations indicated that Ba accumulates with age at about half the rate of Pb accumulation in bone. Concentrations of Ba in rib, ulna and enamel were positively correlated and similar within an individual, but varied among subjects in proportion to variations in absorptive uptake in portal blood. Barium may diffuse from a blood-dentine source into enamel, where it replaces Ca and accumulates with age. Because of extreme Pb pollution of our 80-year-old subjects and its variation of intake with age, the correlation of Pb in tooth enamel with Pb in bone was more scattered than for Ba. It is shown by means of stable Pb isotopic tracers that: (i) among the three types of osseous tissue, the residence time of Pb is longest in enamel, where it apparently accumulates with age by diffusion with little loss through exchange; and (ii) the residence time of Pb is longer in compact ulna than in trabecular rib, as it accompanies Ca in its osteoblastic transfer from blood to bone and then in its osteoclastic transfer back to blood from bone.