The critical period for peripheral specification of dorsal root ganglion neurons is related to the period of sensory neurogenesis.
The critical period for peripheral specification of dorsal root ganglion neurons is related to the period of sensory neurogenesis.
复制标题
背根神经节神经元外周规范的关键期与感觉神经发生期有关。
DOI：
10.1016/0012-1606(90)90369-t
复制
发表时间：
1990
影响因子：
2.7
通讯作者：
Smith,CL
中科院分区：
文献类型：
--
作者：
Smith,CL
在一些胸感觉神经元已经形成连接的阶段，通过将胸神经节移植到臂水平，可以诱导牛蛙蝌蚪的胸感觉神经元形成典型的臂感觉神经元连接。为了弄清有丝分裂后感觉神经元有多少能在移植后存活下来，将[~3H]胸腺嘧啶核苷注射到胸神经节单侧移植到臂丛水平的蝌蚪上，实验时间为VII~IX期。移植神经节中有16%到37%的神经元没有标记，而在未手术的神经节中，这一比例为46%到60%。移植神经节中未标记神经元的数量比相应的未手术神经节少，说明移植引起了有丝分裂后神经元的变性。因此，形成典型臂感觉神经元连接的很大一部分神经元可能是在臂水平上分化的。
Thoracic sensory neurons in bullfrog tadpoles can be induced to form connections typical of brachial sensory neurons by transplanting thoracic ganglia to the brachial level at stages when some thoracic sensory neurons already have formed connections. In order to find out how many postmitotic sensory neurons survive transplantation, [3H]thymidine was administered to tadpoles in which thoracic ganglia were transplanted to the brachial level unilaterally at stages VII to IX. Between 16 and 37% of the neurons in transplanted ganglia were unlabeled, as compared to 46 to 60% in unoperated ganglia. Transplanted ganglia contained fewer unlabeled neurons than corresponding unoperated ganglia, indicating that transplantation caused degeneration of postmitotic neurons. Therefore, a large fraction of the neurons that formed connections typical of brachial sensory neurons probably differentiated while they were at the brachial level.