Sensory denervation of the kidney attenuates renovascular hypertension in the rat.
Sensory denervation of the kidney attenuates renovascular hypertension in the rat.
复制标题
肾脏的感觉去神经支配可减轻大鼠的肾血管性高血压。
DOI：
10.1152/ajpheart.1986.250.1.h82
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Oparil,S
中科院分区：
文献类型：
--
作者：
Wyss,JM;Aboukarsh,N;Oparil,S
为了确定肾传入神经在一肾一夹肾血管性高血压发病机制中的作用，采用背根切断法选择性地切断肾传入神经，这种方法消除了肾对脊髓的感觉输入，但不直接损害肾的交感神经支配。失神经支配一周后，假手术组和去神经对照组大鼠左肾近端肾动脉被夹闭。假手术组的血压在接下来的5周内逐渐升高，达到185毫米汞柱(收缩压)。相比之下，去神经大鼠的血压在临界高血压范围内趋于平稳，这一水平显著低于假手术组，但显著高于未夹闭大鼠。在进一步的两个实验中，这种效应的特异性得到了证明。损毁肾切除侧背根神经对非夹闭大鼠血压无明显影响，对侧背根切断对夹闭大鼠血压无明显影响。这些结果表明，肾传入神经在大鼠一肾一夹肾血管性高血压中起重要作用。
To determine the role of the renal afferent nerves in the pathogenesis of one-kidney, one-clip renovascular hypertension, the renal afferent nerves were selectively lesioned by dorsal rhizotomy, a procedure that eliminates renal sensory input to the spinal cord but does not directly damage the sympathomotor innervation of the kidney. One week after denervation, the proximal left renal artery was clipped in denervated and sham control rats. Blood pressure of the sham group rose progressively over the next 5 wk, to 185 mmHg (systolic). In contrast, blood pressure of the denervated rats leveled off in the borderline hypertensive range, a level significantly lower than that of the sham group but significantly higher than that of non-clipped rats. In two further experiments the specificity of this effect was demonstrated. Lesion of the dorsal root nerves on the side of nephrectomy did not significantly lower blood pressure of non-clipped rats, and contralateral dorsal rhizotomy did not lower the blood pressure of clipped rats. These results demonstrate that the renal afferent nerves significantly contribute to one-kidney, one-clip renovascular hypertension in the rat.