Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway.
Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway.
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DOI：
10.1038/s41598-021-90707-4
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发表时间：
2021-05-26
影响因子：
4.6
通讯作者：
Fujiya M
中科院分区：
文献类型：
--
作者：
Konishi H;Isozaki S;Kashima S;Moriichi K;Ichikawa S;Yamamoto K;Yamamura C;Ando K;Ueno N;Akutsu H;Ogawa N;Fujiya M
摄入益生菌或由某些益生菌产生的发酵食品被认为对包括胰腺癌在内的各种癌症发挥抗肿瘤功能，因为已有多项研究在动物致癌模型中证明了益生菌的体外和体内抗肿瘤作用。然而，益生菌对胰腺癌的抗癌作用的机制尚未阐明。在这项研究中，我们评估了益生菌对胰腺癌细胞的抗肿瘤作用。在已知的益生菌中，Aspergilluslavis表现出强烈的胰腺肿瘤抑制作用。A.通过HPLC分离了C18。庚内酯酸是一种来源于A.通过LC-MS和NMR分析鉴定。在胰腺癌细胞的异种移植模型中，在体外和体内显示出庚替酸的抗肿瘤作用。heptelidic acid的抗肿瘤作用是通过p38 MAPK信号通路实现的。庚酸穿过肠粘膜并对胰腺癌细胞发挥抗肿瘤作用。这是有益菌诱导胰腺癌的一种新的抗肿瘤机制，其中细菌分子通过肠道，到达肠外器官，然后通过可诱导的信号通路诱导细胞凋亡。
Intake of probiotics or fermented food produced by some probiotic bacteria is believed to exert anti-tumor functions in various cancers, including pancreatic cancer, because several studies have demonstrated the anti-tumor effects of probiotic bacteria in vitro and in vivo in animal carcinogenesis models. However, the mechanisms underlying the anticancer effects of probiotics on pancreatic cancer have not been clarified. In this study, we assessed the anti-tumor effects of probiotic bacteria against pancreatic cancer cells. Among the known probiotic bacteria, Aspergillus oryzae exhibited a strong pancreatic tumor suppression effect. The culture supernatant of A. oryzae was separated by HPLC. Heptelidic acid was identified as an anti-tumor molecule derived from A. oryzae by LC–MS and NMR analysis. The anti-tumor effect of heptelidic acid was exhibited in vitro and in vivo in a xenograft model of pancreatic cancer cells. The anti-tumor effect of heptelidic acid was exerted by the p38 MAPK signaling pathway. Heptelidic acid traverses the intestinal mucosa and exerts anti-tumor effects on pancreatic cancer cells. This is a novel anti-tumor mechanism induced by beneficial bacteria against pancreatic cancer in which bacterial molecules pass through the intestinal tract, reach the extra-intestinal organs, and then induce apoptosis via an inducible signaling pathway.
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益生菌衍生的铁晶体通过JNK介导的凋亡抑制结肠癌的进展。
影响因子：
16.6
作者：
Konishi H;Fujiya M;Tanaka H;Ueno N;Moriichi K;Sasajima J;Ikuta K;Akutsu H;Tanabe H;Kohgo Y
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影响因子：
64.5
作者：
Riquelme, Erick;Zhang, Yu;McAllister, Florencia
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McAllister, Florencia
影响因子：
29
作者：
Liberti MV;Dai Z;Wardell SE;Baccile JA;Liu X;Gao X;Baldi R;Mehrmohamadi M;Johnson MO;Madhukar NS;Shestov AA;Chio IIC;Elemento O;Rathmell JC;Schroeder FC;McDonnell DP;Locasale JW
通讯作者：
Locasale JW
影响因子：
2.9
作者：
HSIEH, PC;SHENOY, BC;PHILLIPS, NFB
通讯作者：
PHILLIPS, NFB