The Mayo Clinic Biobank: a building block for individualized medicine.
The Mayo Clinic Biobank: a building block for individualized medicine.
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DOI：
10.1016/j.mayocp.2013.06.006
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发表时间：
2013-09
影响因子：
8.9
通讯作者：
Cerhan JR
中科院分区：
文献类型：
--
作者：
Olson JE;Ryu E;Johnson KJ;Koenig BA;Maschke KJ;Morrisette JA;Liebow M;Takahashi PY;Fredericksen ZS;Sharma RG;Anderson KS;Hathcock MA;Carnahan JA;Pathak J;Lindor NM;Beebe TJ;Thibodeau SN;Cerhan JR
报告马约诊所生物样本库的设计和前三年的入组情况。该生物库的筹备工作始于与当地居民进行为期4天的协商性社区参与，以获得社区对生物库设计和管理的投入。征聘工作于2009年4月开始，目前正在进行，目标是50 000人。任何年满18岁、能够签署知情同意书且为美国居民的马约诊所患者都有资格参加研究。每位参与者完成一份健康史调查问卷，提供一份血液样本，并允许访问现有的组织标本和来自其马约诊所病历（EMR）的所有数据。社区咨询委员会就复杂的决定提供持续的建议和指导。经过三年的招募，已招募了21，736名受试者。参与者中58%为女性，95%为欧洲血统，中位年龄为62岁。74%的人住在明尼苏达州，42%来自马约诊所罗切斯特所在的奥姆斯特德县。五种最常见的自我报告疾病是高脂血症（41%）、高血压（38%）、骨关节炎（30%）、任何癌症（29%）和胃食管反流病（26%）。在自我报告的癌症患者中，五种最常见的类型是非黑色素瘤皮肤癌（14%），前列腺癌（男性12%），乳腺癌（4%），黑色素瘤（3%）和宫颈癌（女性2%）。五十六%的参与者至少有15年的EMR病史。迄今为止，已批准使用60多个项目和69 000多个样本。马约诊所生物库已迅速成为研究人员的宝贵资源。
To report the design and first three years of enrollment of the Mayo Clinic Biobank. Preparations for this Biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing with a target goal of 50,000. Any Mayo Clinic patient who is 18+ years, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample and allows access to existing tissue specimens and all data from their Mayo Clinic medical record (EMR). A Community Advisory Board provides ongoing advice and guidance on complex decisions. After three years of recruitment, 21,736 subjects have enrolled. Participants were 58% female, 95% of European ancestry, and median age of 62 years. Seventy-four percent lived in Minnesota, 42% from Olmsted County where the Mayo Clinic Rochester is located. The five most commonly self-reported conditions were hyperlipidemia (41%), hypertension (38%), osteoarthritis (30%), any cancer (29%), and gastroesophageal reflux disease (26%). Among self-reported cancer patients, the five most common types were non-melanoma skin cancer (14%), prostate cancer (12% in men), breast cancer (4%), melanoma (3%), and cervical cancer (2% in women). Fifty-six percent of participants had at least 15 years of EMR history. To date, over sixty projects and over 69,000 samples have been approved for use. The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers.
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DOI：
10.1016/0277-5379(83)90096-2
发表时间：
1983-01-01
期刊：
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY
影响因子：
--
作者：
COATES, A;DILLENBECK, CF;TATTERSALL, MHN
通讯作者：
TATTERSALL, MHN
影响因子：
5.1
作者：
Li, Chaoyang;Balluz, Lina S.;Pierannunzi, Carol
通讯作者：
Pierannunzi, Carol
影响因子：
5.4
作者：
Secko, David M.;Preto, Nina;Burgess, Michael M.
通讯作者：
Burgess, Michael M.
影响因子：
12.7
作者：
Nelson, DE;Powell-Griner, E;Kovar, MG
通讯作者：
Kovar, MG
影响因子：
2.3
作者：
McCarty, Catherine A;Wilke, Russell A;Caldwell, Michael D
通讯作者：
Caldwell, Michael D