Plant targets for Pseudomonas syringae type III effectors: virulence targets or guarded decoys?
Plant targets for Pseudomonas syringae type III effectors: virulence targets or guarded decoys?
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DOI：
10.1016/j.mib.2010.12.011
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发表时间：
2011-02
影响因子：
5.4
通讯作者：
Alfano JR
中科院分区：
文献类型：
--
作者：
Block A;Alfano JR
植物病原性细菌假单胞菌（Pseudomonaserichingae）可通过向宿主细胞中注射III型效应子（T3E）蛋白来抑制病原体相关分子模式（PAMP）触发的免疫（PTI）和效应子触发的免疫（ETI）。T3E使用多种策略实现免疫抑制，包括干扰免疫受体信号传导、阻断RNA途径和囊泡运输以及改变细胞器功能。T3E可以直接或间接地被监测导致ETI的特异性T3E靶标的抗性蛋白识别。目前尚不清楚监测的目标是真正的毒力目标还是有保护的诱饵。PTI和ETI信号传导之间的广泛重叠表明，T3E可以通过共同的靶点和通过具有多种活性来抑制这两种途径。
The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized directly or indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities.