Nutritional rickets in Denmark: a retrospective review of children's medical records from 1985 to 2005
Nutritional rickets in Denmark: a retrospective review of children's medical records from 1985 to 2005
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DOI：
10.1007/s00431-008-0864-1
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发表时间：
2009-08-01
影响因子：
3.6
通讯作者：
Brock-Jacobsen, Bendt
中科院分区：
文献类型：
--
作者：
Beck-Nielsen, Signe Sparre;Jensen, Tina Kold;Brock-Jacobsen, Bendt
介绍本研究描述了在丹麦儿童中诊断营养性佝偻病的临床和生化特征及危险因素。所有的病历佝偻病患者提到或出院的医院在南部丹麦从1985年至2005年被确定登记search.Materials和方法患者包括年龄小于15岁，符合诊断标准的主要，营养性佝偻病。共纳入112例营养性佝偻病患者：29人是丹麦裔，和83名immigration.Results患者诊断前4岁（中位数1.4）显示佝偻病的经典临床体征，而患者诊断后4岁（中位数12.5）年的临床体征和非特异性症状很少。丹麦族患者仅在24个月大之前被诊断出，他们占所有出现低钙癫痫发作病例的73%，但在生化方面，他们没有更严重的佝偻病。在4岁之前确诊的患者中，45%是丹麦人。在幼儿期，88%的病例中维生素D补充不足或没有补充。在移民女孩年龄大于4岁，78%被veiled.Discussion营养性佝偻病在丹麦主要是一种疾病的移民，但丹麦族患者包括近一半的所有患者诊断前4岁，他们提出更频繁的低钙癫痫发作。主要的风险因素被忽略，如最年轻的患者中的维生素D预防和年龄较大的儿童/青少年中的面纱。
Introduction This study describes clinical and biochemical characteristics of nutritional rickets and risk factors at diagnosis among children living in Denmark. All medical records from patients with rickets referred to or discharged from hospitals in Southern Denmark from 1985 to 2005 were identified by register search.Materials and methods Patients included were younger than 15 years of age and fulfilled the diagnostic criteria of primary, nutritional rickets. A total of 112 patients with nutritional rickets were included: 29 were of ethnic Danish origin, and 83 were immigrants.Results Patients diagnosed before the age of 4 (median 1.4) years displayed the classic clinical signs of rickets, whereas patients diagnosed after the age of 4 (median 12.5) years had few clinical signs and unspecific symptoms. Ethnic Danish patients were only diagnosed before age 24 months, and they accounted for 73% of all cases presenting with hypocalcemic seizures, but biochemically, they did not have more severe rickets. Of patients diagnosed before the age of 4 years, 45% were ethnic Danish. In early childhood, insufficient or no vitamin D supplementation was given in 88% of all cases. Among immigrant girls older than 4 years of age, 78% were veiled.Discussion Nutritional rickets in Denmark is predominantly a disease among immigrants, but ethnic Danish patients comprised nearly half of all patients diagnosed before the age of 4 years, and they presented more frequently with hypocalcemic seizures. The main risk factors were omitted, such as vitamin D prophylaxis among the youngest patients and veiling among older children/teenagers.