The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses.
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses.
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DOI：
10.1016/j.jpeds.2009.12.008
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发表时间：
2010-06
影响因子：
5.1
通讯作者：
Ziegler, Thomas R.
中科院分区：
文献类型：
--
作者：
Cole, Conrad R.;Frem, Juliana C.;Schmotzer, Brian;Gewirtz, Andrew T.;Meddings, Jonathan B.;Gold, Benjamin D.;Ziegler, Thomas R.
这项在短肠综合征（SBS）肠外营养（PN）依赖婴儿中进行的初步研究评价了喂养途径和肠道通透性对血流感染（BSI）、小肠细菌过度生长（SBBO）和全身免疫反应的影响，以及粪便钙卫蛋白作为SBBO的生物标志物。对10名因坏死性小肠结肠炎而患有SBS的婴儿（年龄4.2-15.4个月）进行了评价。在基线、第60天和第120天进行营养评估、呼气氢检测、肠通透性、粪便钙卫蛋白、血清鞭毛蛋白和LPS特异性抗体滴度以及促炎细胞因子浓度（TNF-α、IL-1 β、IL-6、IL-8）。招募了健康、年龄匹配的对照组（n=5）。BSI发病率高（80%），SBBO常见（50%）。SBBO增加了BSI的几率（> 7倍; p=0.009）。SBS和SBBO儿童的钙卫蛋白水平高于无SBBO儿童和健康对照组（p<0.05）。与对照组相比，基线时血清TNF-α升高。血清TNF-α、IL-1 β、IL-6和IL-8水平随肠内营养增加而降低。与对照组相比，SBS儿童的抗鞭毛蛋白和抗LPS IgG水平较低，并随着时间的推移而上升。在SBS儿童中，SBBO增加了BSI的风险，全身促炎反应随着肠内喂养和撤机PN的增加而降低。
This pilot study in parenteral nutrition (PN) dependent infants with short bowel syndrome (SBS) evaluated the impact of feeding route and intestinal permeability on bloodstream infection (BSI), small bowel bacterial overgrowth (SBBO) and systemic immune responses, and fecal calprotectin as a biomarker for SBBO. 10 infants (ages 4.2-15.4 months) with SBS due to necrotizing enterocolitis were evaluated. Nutritional assessment, breath hydrogen testing, intestinal permeability, fecal calprotectin, serum flagellin- and LPS- specific antibody titers, and proinflammatory cytokine concentrations (TNF-α, IL-1 β, IL-6, IL-8) were performed at baseline, 60 and 120 days. Healthy, age-matched controls (n=5) were recruited. BSI incidence was high (80%) and SBBO was common (50%). SBBO increased the odds for BSI (> 7-fold; p=0.009). Calprotectin levels were higher in children with SBS and SBBO versus those without SBBO and healthy controls (p<0.05). Serum TNF-α, was elevated at baseline versus controls. Serum TNF-α, IL-1 β, IL-6 and IL-8 levels diminished with increased enteral nutrition. Anti-flagellin and anti-LPS IgG levels in children with SBSwere lower versus controls and rose over time. In children with SBS, SBBO increases the risk for BSI and systemic proinflammatory response decreases with increasing enteral feeding and weaning PN.
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影响因子：
2.5
作者：
Gewirtz, AT
通讯作者：
Gewirtz, AT
影响因子：
29.4
作者：
CORAZZA, GR;MENOZZI, MG;GASBARRINI, G
通讯作者：
GASBARRINI, G
影响因子：
5.1
作者：
deBoissieu, D;Chaussain, M;Dupont, C
通讯作者：
Dupont, C
影响因子：
3.6
作者：
Sigalet, DL;Martin, G;Holst, JJ
通讯作者：
Holst, JJ
影响因子：
2.4
作者：
Diamond, Ivan R.;de Silva, Nicole;Wales, Paul W.
通讯作者：
Wales, Paul W.